Prediction of Creatinine Clearance from Serum Creatinine

Abstract

A formula has been developed to predict creatinine clearance (C_cr) from serum creatinine (S_cr) in adult males: Ccr = (140 – age) (wt kg)/72 × S_cr(mg/100ml) (15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18–92. Values for C_cr were predicted by this formula and four other methods and the results compared with the means of two 24-hour C_cr’s measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr·s of 0.83; on average, the difference between predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction.

Frequency and Outcomes of Reduced Dose Non–Vitamin K Antagonist Anticoagulants: Results From ORBIT‐AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II)

“…CHA 2 DS 2 VASc is a rating of risk for stroke in patients with atrial fibrillation; FDA, Food and Drug Administration; LVEF, left‐ventricular ejection fraction; NOAC, non–vitamin K antagonist oral anticoagulant; ORBIT, Outcomes Registry for Better Informed Treatment; TIA, transient ischemic attack.aAs calculated by the Cockcroft‐Gault formula 13…”

“…The dosing categorization was calculated using all relevant data (creatinine, creatinine clearance using the Cockroft‐Gault estimation,13 weight, age, and/or concomitant medications), as previously reported 9. This included both doses prescribed that were higher than recommended (or contraindicated) and those that were lower than recommended.…”

Development of an estimated glomerular filtration rate formula in cats

“…The precision and accuracy of the formulas are questionable, particularly in elderly patients, patients with extremes of muscle mass, and in patients with unstable renal function. Furthermore, the earlier formulas3, 4 may underestimate true GFR leading to misclassification of some patients as having CKD. In human patients, the correlation coefficient ( r ) between GFR and eGFR predicted by the Cockcroft‐Gault formula was 0.83 and mean percentage error (expressed as a percentage of true GFR) was 35% in 95% of patients 3.…”

“…It is now mandatory for eGFR to be reported with every serum creatinine concentration measurement performed in human patients in several states in the United States, in the United Kingdom, and in Australia,2 highlighting the importance of such formulas. The most widely used prediction formulas for GFR in human patients are the Cockcroft‐Gault,3 Modification of Diet in Renal Disease (MDRD),4 and Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) formulas5 (Table 1). These formulas estimate GFR from serum creatinine concentration by means of prediction equations that take into account of factors such as age, sex, race, and body size 3, 4, 5.…”

“…The most widely used prediction formulas for GFR in human patients are the Cockcroft‐Gault,3 Modification of Diet in Renal Disease (MDRD),4 and Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) formulas5 (Table 1). These formulas estimate GFR from serum creatinine concentration by means of prediction equations that take into account of factors such as age, sex, race, and body size 3, 4, 5. After introduction of reporting of eGFR alongside serum creatinine concentration, recognition of CKD by doctors has increased 6…”