2022
DOI: 10.1101/2022.03.23.22272846
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Prediction of CRT Response Using a Lead Placement Score Derived from 4DCT

Abstract: Background: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with heart failure; however, 30% of patients do not respond to the treatment. We sought to derive patient-specific left-ventricle (LV) maps of lead placement scores (LPS) that highlight target pacing lead sites for achieving a higher probability of CRT response. Methods: Eighty-two subjects recruited for the ImagingCRT trial were retrospectively analyzed. All 82 subjects had two contrast-enhanced full-cardiac cycle 4DCT … Show more

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Cited by 1 publication
(4 citation statements)
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“…The main findings of this study reveal the clinical utility of ResyncCT in minimizing gantry-induced false dyssynchrony artifacts in cardiac 4DCT images; this is especially important when estimating the mechanical activation time of the myocardium as ‘times to onset of shortening’ from cardiac 4DCT images of subjects under consideration for CRT. In 23/24 subjects in this study, ResyncCT could have a significant effect in potentially reclassifying the subjects based on their probability of responding to CRT [16]. The TOS is the most prominent feature in determining the probability of CRT response; a change in TOS of greater than 35 ms could significantly change the estimated probability of a subject responding to CRT; thus, the accurate and precise estimation of TOS from 4DCT is essential.…”
Section: Discussionmentioning
confidence: 99%
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“…The main findings of this study reveal the clinical utility of ResyncCT in minimizing gantry-induced false dyssynchrony artifacts in cardiac 4DCT images; this is especially important when estimating the mechanical activation time of the myocardium as ‘times to onset of shortening’ from cardiac 4DCT images of subjects under consideration for CRT. In 23/24 subjects in this study, ResyncCT could have a significant effect in potentially reclassifying the subjects based on their probability of responding to CRT [16]. The TOS is the most prominent feature in determining the probability of CRT response; a change in TOS of greater than 35 ms could significantly change the estimated probability of a subject responding to CRT; thus, the accurate and precise estimation of TOS from 4DCT is essential.…”
Section: Discussionmentioning
confidence: 99%
“…The TOS has previously been shown to be an excellent metric to quantify LV dyssynchrony [6]-[8] and is also strongly correlated with CRT response [9]—[11]. From our previous study, it was determined that a shift in TOS (|ΔTOS|) of 35 ms will cause a significant shift in the classification of patients between low, mid, and high probability of CRT response [16]. In this study, the effect of ResyncCT was evaluated by observing the number of LV segments (as % LV surface area) that experienced a change in TOS estimates by greater than |35| ms between the uncorrected and the ResyncCT images for each subject.…”
Section: Methodsmentioning
confidence: 99%
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