2024
DOI: 10.1021/acs.analchem.4c02025
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Prediction of Degradation Profiles for Various Sartans under Solvent-Free Mechanochemical Conditions

Mostafa M. Amer,
Laura Backer,
Helmut Buschmann
et al.

Abstract: For the approval of a drug, the stability data must be submitted to regulatory authorities. Such analyses are often time-consuming and costintensive. Forced degradation studies are mainly carried out under harsh conditions in the dissolved state, often leading to extraneous degradation profiles for a solid drug. Oxidative mechanochemical degradation offers the possibility of generating realistic degradation profiles. In this study, a sustainable mechanochemical procedure is presented for the degradation of fiv… Show more

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