In this paper, the effects of maximum load, load ratio, and average load on fatigue crack propagation of Zr702/TA2/Q345R composite plate with a crack normal to the interface are studied by experiment and finite element method. When crack propagates to the interface from the compliant material side, the crack growth rate decreases to the minimum at first. After crack penetrates through the interface, the fatigue crack growth rate accelerates continuously. When crack propagates to the interface from the stiff material side, the fatigue crack growth rate generally increases with the crack length. Regardless of the direction of crack growth, the increase of load ratio will weaken the difference of crack growth rate near the interface caused by material property mismatch. Finite element results show that elastic modulus mismatch significantly changes the variation of the stress intensity factor amplitude. All results demonstrate that crack growth rate is dependent on the competition of the stress intensity factor amplitude, the fatigue crack growth rate in the corresponding material, and the interface strength.