Prediction of Dementia by Subjective Memory Impairment&lt;subtitle&gt;Effects of Severity and Temporal Association With Cognitive Impairment&lt;/subtitle&gt;&lt;alt-title&gt;Dementia and Subjective Memory Impairment&lt;/alt-title&gt;

Jessen, Frank; Wiese, Birgitt; Bachmann, Cadja; Eifflaender-Gorfer, Sandra; Haller, Franziska; Kölsch, Heike; Luck, Tobias; Mösch, Edelgard; Bussche, Hendrik van den; Wagner, Michael; Wollny, Anja; Zimmermann, Thomas; Pentzek, Michael; Riedel‐Heller, Steffi G.; Romberg, Heinz-Peter; Weyerer, Siegfried; Kaduszkiewicz, Hanna; Maier, Wolfgang; Bickel, Horst

doi:10.1001/archgenpsychiatry.2010.30

Cited by 603 publications

(464 citation statements)

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“…SMCs are common in the elderly population without dementia, with an estimated prevalence range between 22% and 56%, 1 and have been associated with increased risk of incident Alzheimer disease (AD). 2 Despite the high prevalence of self-perceived changes in memory among older adults, relatively little is known about its functional and pathologic correlates, especially in the preclinical stages of AD. This information is crucial because SMCs alone may have insufficient sensitivity and specificity to predict the development of dementia.…”

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confidence: 99%

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden

et al. 2017

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Objective: To identify the functional and pathologic correlates underlying subjective memory complaints (SMCs) in cognitively normal older adults.Methods: Two hundred fifty-one older adults underwent resting-state fluorodeoxyglucose (FDG)-PET and Pittsburg compound B-PET b-amyloid (Ab) imaging and filled out a questionnaire regarding SMCs. Participants were classified into 2 groups based on their Ab burden. Age-adjusted voxel-wise correlations were used to examine SMCs, amyloid status (Ab 1 vs Ab 2 ), and the interaction between SMCs and Ab status as predictors of metabolism. Region-of-interest (ROI) analyses were performed to confirm the whole-brain analyses and to test for additional covariates.Results: Greater SMCs correlated with decreased FDG metabolism in the bilateral precuneus, bilateral inferior parietal lobes, right inferior temporal lobe, right medial frontal gyrus, and right orbitofrontal gyrus. A significant interaction effect between SMCs and amyloid burden was found such that Ab 1 individuals with increased complaints had decreased FDG metabolism in the bilateral medial temporal lobes. ROI analyses confirmed the voxel-wise analyses result in that decreased precuneus metabolism was associated with greater SMCs regardless of Ab status, age, or thickness, whereas the relationship between hippocampal metabolism and SMCs was a function of Ab, even after adjustment for age, hippocampal volume, or depressive symptoms.Conclusions: These data show the relevant role of posterior and anterior midline regions in SMCs in older individuals. Decreased hippocampal metabolism may be a specific marker of subclinical changes in cognition due to amyloid pathology. However, longitudinal studies are needed to determine whether our findings foreshadow clinical decline. Neurology ® 2017;88:1759-1767 GLOSSARY Ab 5 b-amyloid; AD 5 Alzheimer disease; CN 5 cognitively normal; FDG 5 fluorodeoxyglucose; FDR 5 false discovery rate; GDS 5 Geriatric Depression Scale; MFG 5 middle frontal gyrus; MGH 5 Massachusetts General Hospital; MTL 5 medial temporal lobe; PiB 5 Pittsburg compound B; ROI 5 region of interest; SMC 5 subjective memory complaint.Subjective memory complaint (SMC) is defined by self-reports of memory worsening and objective memory performance in the normal adjusted range. SMCs are common in the elderly population without dementia, with an estimated prevalence range between 22% and 56%, 1 and have been associated with increased risk of incident Alzheimer disease (AD). 2 Despite the high prevalence of self-perceived changes in memory among older adults, relatively little is known about its functional and pathologic correlates, especially in the preclinical stages of AD. This information is crucial because SMCs alone may have insufficient sensitivity and specificity to predict the development of dementia.With regard to SMCs and b-amyloid (Ab; one hallmark of AD pathology most commonly used to define the preclinical stage), previous studies have found conflicting results. Whereas most studies have reported an a...

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confidence: 99%

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden

et al. 2017

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“…Studies of brain activity during cognitive tasks note that subjects with SMC present an increase in activity in comparison with the control group (Rodda et al 2009;Rodda et al 2010;Maestu et al 2010;Jessen et al 2010;Elfgren et al 2010;Gallassi et al 2010;Benito-León et al 2010;Luck et al 2010). All these studies have evaluated the spatial or the spatiotemporal profiles of activity, but none of them assess whether the functional connectivity between brain regions was spared or not in subjects with SMC.…”

Section: Introductionmentioning

confidence: 99%

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

Bajo

Castellanos

López

et al. 2011

AGE

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It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects.

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“…Possible responses were "No," "Yes, but this does not worry me," or "Yes, this worries me"). 20 Individuals also needed to have the ability to make and receive phone calls and text messages, access to a desktop computer with video-teleconferencing and a reliable internet connection, and be motivated to use a daily coaching program. Individuals were excluded if they had a significant history of dementia, mental illness, substance abuse, learning disability, or neurologic conditions, had ophthalmologic/visual problems (e.g., legal blindness, detached retinas, occlusive cataracts) that prevented them from viewing a computer screen at a normal distance, were currently participating in a formal cognitive-training coaching program, or were currently pregnant.…”

Section: Recruitment and Screeningmentioning

confidence: 99%

The Impact of the Virtual Cognitive Health Program on the Cognition and Mental Health of Older Adults: Pre-Post 12-Month Pilot Study (Preprint)

Kumar¹,

Tran²,

Moseson³

et al. 2018

Preprint

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Prediction of Dementia by Subjective Memory Impairment<subtitle>Effects of Severity and Temporal Association With Cognitive Impairment</subtitle><alt-title>Dementia and Subjective Memory Impairment</alt-title>

Abstract: The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.

Cited by 603 publications

References 38 publications

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden

Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

The Impact of the Virtual Cognitive Health Program on the Cognition and Mental Health of Older Adults: Pre-Post 12-Month Pilot Study (Preprint)

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