Prediction of depressive relapse in remitted bipolar patients using corticotrophin‐releasing hormone challenge test

Vieta, Eduard; Gastó, Cristòbal; Osaba, M. Jesús Martínez de; Nieto, E.; Cantó, T. J.; Otero, A.; Vallejo, Julio

doi:10.1111/j.1600-0447.1997.tb09621.x

Cited by 35 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The criteria of remission for bipolar patients were a score of 6 or less in the Young Mania Rating Scale [20], a score of 8 or less in the Hamilton Depression Rating Scale [21]and an at least 6-month remission. These criteria had been shown to be valid and reliable in previous investigations [22, 23]. Only patients aged between 18 and 60 years were included.…”

Section: Methodsmentioning

confidence: 99%

Executive Function in Patients with Remitted Bipolar Disorder and Schizophrenia and Its Relationship with Functional Outcome

Martínez‐Arán

Penadés

Vieta

et al. 2001

Psychother Psychosom

Self Cite

167

121

View full text Add to dashboard Cite

Background: Recent studies have reported that differences in cognitive performance between schizophrenic and bipolar patients seem to be smaller than expected. Patients with schizophrenia have consistently shown frontal executive dysfunctions, but studies regarding executive abilities in bipolar patients are scarce and discrepant. As executive function has been associated with psychosocial functioning in schizophrenia, we wanted to investigate if such a relationship is also present in bipolar disorder and the differences between the two groups. Methods: Executive function was assessed in 49 euthymic (at least 6 months in remission, Hamilton Depression Rating Scale ≤8 and Young Mania Rating Scale ≤6) bipolar and in 49 schizophrenic, residual-type (with at least 1 year without acute exacerbation and predominant negative symptomatology) patients, by the Wisconsin Card Sorting Test (WCST), FAS Test (COWAT) and Trail Making Test. Baseline clinical and psychosocial variables were controlled and psychopathology evaluated by means of the Positive and Negative Syndrome Scale (PANSS). Results: The two groups showed a similar pattern of cognitive deficits in tests of executive function, except for the number of categories achieved in the WCST, which was significantly lower in the schizophrenic group (F = 7.26; p = 0.009). Functional outcome was predicted by the negative syndrome (PANSSN) and perseverative errors (WCST) in schizophrenic patients, and general psychopathology (PANSSG) was the best predictor of functional outcome in the bipolar group. Conclusion: Executive function was a good predictor of functional outcome in the schizophrenic group, whereas clinical variables were more predictive of the bipolar one. Patterns of cognitive disturbances in tasks of executive function are similar in both groups but quantitatively more marked in schizophrenia.

show abstract

Section: Methodsmentioning

confidence: 99%

Executive Function in Patients with Remitted Bipolar Disorder and Schizophrenia and Its Relationship with Functional Outcome

Martínez‐Arán

Penadés

Vieta

et al. 2001

Psychother Psychosom

Self Cite

167

121

View full text Add to dashboard Cite

show abstract

“…Cognitive dysfunctions may be markers of vulnerability to relapse [111]as well as neurobiological disturbances underlying the euthymic state [149, 150]. …”

Section: Future Directionsmentioning

confidence: 99%

Cognitive Dysfunctions in Bipolar Disorder: Evidence of Neuropsychological Disturbances

Martínez‐Arán¹,

Vieta²,

Colom³

et al. 1999

Psychother Psychosom

202

139

View full text Add to dashboard Cite

Although cognitive dysfunctions in psychosis have classically been associated with schizophrenia, there is clinical evidence that some bipolar patients show cognitive disturbances either during acute phases or in remission periods. The authors critically review the data on cognitive impairment in bipolar disorder. The main computerized databases (Medline, Psychological Abstracts, Current Contents) have been consulted crossing the terms ‘cognitive deficits’, ‘neuropsychology’, ‘intellectual impairment’, ‘mania’, ‘depression’ and ‘bipolar disorder’. Changes in the fluency of thought and speech, learning and memory impairment, and disturbances in associational patterns and attentional processes are as fundamental to depression and mania as are changes in mood and behavior. Moreover, a significant number of bipolar patients show persistent cognitive deficits during remission from affective symptoms. However, there are several methodological pitfalls in most studies such as unclear remission criteria, diagnostic heterogeneity, small sample sizes, absence of longitudinal assessment, practice effect and poor control of the influence of pharmacological treatment. Most studies point at the presence of diffuse cognitive dysfunction during the acute phases of bipolar illness. Most of these deficits seem to remit during periods of euthymia, but some of them may persist in approximately one third of bipolar patients. Methodological limitations warrant further research in order to clear up the relationship between neuropsychological functioning and clinical, demographic and treatment variables in bipolar disorder.

show abstract

“…BD has been associated with hyperactivity of the HPA axis and with a dysfunctional response to stress. Both factors have been implicated in increases of vulnerability to mood episodes [75][76][77][78][79].…”

Section: A U T H O R P R O O Fmentioning

confidence: 99%

Insulin dysfunction and allostatic load in bipolar disorder

Brietzke

Kapczinski

Grassi‐Oliveira

et al. 2011

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

Bipolar disorder (BD) is associated with substantial morbidity, as well as premature mortality. Available evidence indicates that 'stress-sensitive' chronic medical disorders, such as cardiovascular disease, obesity and Type 2 diabetes mellitus, are critical mediators and/or moderators of BD. Changes in physiologic systems implicated in allostasis have been proposed to impact brain structures and neurocognition, as well as medical comorbidity in this population. For example, abnormalities in insulin physiology, for example, insulin resistance, hyperinsulinemia and central insulinopenia, are implicated as effectors of allostatic load in BD. Insulin's critical role in CNS physiological (e.g., neurotrophism and synaptic plasticity) and pathophysiological (e.g., neurocognitive deficits, pro-apoptosis and amyloid deposition) processes is amply documented. This article introduces the concept that insulin is a mediator of allostatic load in the BD and possibly a therapeutic target.

show abstract

Prediction of depressive relapse in remitted bipolar patients using corticotrophin‐releasing hormone challenge test

Cited by 35 publications

References 26 publications

Executive Function in Patients with Remitted Bipolar Disorder and Schizophrenia and Its Relationship with Functional Outcome

Executive Function in Patients with Remitted Bipolar Disorder and Schizophrenia and Its Relationship with Functional Outcome

Cognitive Dysfunctions in Bipolar Disorder: Evidence of Neuropsychological Disturbances

Insulin dysfunction and allostatic load in bipolar disorder

Contact Info

Product

Resources

About