Prediction of drug solubility in ethylene glycol + water mixtures using generally trained cosolvency models

Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods

“…In aqueous solvent, there was a decline in recoveries of CPM up to 41% while a similar decreasing trend in % recovery of CPM was observed at 35% in the case of aq-MeOH and aq-EG system. CPM is a freely soluble active pharmaceutical ingredient in the studied solvent systems (water, methanol, and ethylene glycol) [37]. Therefore, a similar retention time was observed with studied solvents (1.89 min) while a drift in retention was found comparatively with Std.…”

Revealing the Molecular Mechanism of Cosolvency Based on Thermodynamic Phase Diagram, Molecular Simulation, and Spectrum Analysis: The Tolbutamide Case

“…Many experimental results and data on the cosolvency of various systems have been obtained by various research groups. Many studies on cosolvency were focused on the modeling of the solubilities in pure solvents to predict the cosolvency effect. , And many mathematical models have been used to estimate the solubility of compounds in the cosolvency systems, including the NRTL model, the combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R-K) model, fluctuation theory, the Jouyban–Acree model, , the modified Wilson model, the excess free energy approach, the mixture response surface, the phenomenological model and so on. However, these models did not reveal the essential reason for cosolvency at the molecular level.…”