Prediction of Early Clinical Severity and Extent of Neuronal Damage in Anterior-Circulation Infarction Using the Initial Serum Neuron-Specific Enolase Level

Oh, Sang Ho; Lee, Jin Goo; Na, Sang-Jun; Park, Ji‐Hyung; Choi, Young Chul; Kim, Won Joo

doi:10.1001/archneur.60.1.37

Cited by 64 publications

(53 citation statements)

References 33 publications

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“…Best correlations with infarct volume were found for the 2-to-4-day interval after stroke. 12,17 In this time interval, we found an association between S100␤ concentrations and the presence and volume of postoperative DWI lesion. However, on the level of single measurements (Figure 4), we doubt the clinical usefulness of this parameter for identifying patients with perioperative embolic brain lesions because the lesion volume in these patients is generally small and the power of S100␤ to separate groups with or without postoperative DWI lesions is weak.…”

Section: Discussionmentioning

confidence: 57%

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Diffusion-Weighted Magnetic Resonance Imaging and Neurobiochemical Markers After Aortic Valve Replacement

Stolz

Gerriets

Kluge

et al. 2004

Stroke

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Background and Purpose-Cardiac surgery carries a high risk of neurological complications; therefore, these patients would be an appropriate target population for neuroprotective strategies. In this study, we evaluated postoperative diffusion-weighted imaging (DWI) as a potential surrogate marker for brain embolism and its relationship to neurobiochemical markers of brain injury. Methods-Of a total of 45 consecutive patients undergoing aortic valve replacement, 37 completed preoperative and postoperative MRI. At the time of the MRI studies, serum S100␤ and neuron-specific enolase concentrations were determined. Preexisting T2 and postoperative DWI lesion volumes were quantified. All patients had a blinded neurological examination before and after operation. Results-New perioperative DWI lesions were present in 14 patients (38%), of whom only 3 developed focal neurological deficits. Eighteen small lesions were found in the white matter or vascular border zones in all but 2 patients with territorial stroke. The appearance of new DWI lesions correlated with age, pre-existing T2 lesion volume, and postoperative S100␤ concentrations on days 2 to 4 after surgery. In a forward stepwise canonical discrimination model, only T2 lesion volume was selected as a relevant variable. Conclusions-The

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Section: Discussionmentioning

confidence: 57%

“…S100␤ and NSE concentrations have been found to correlate closely with the volume of territorial ischemic stroke. 12,17 However, timing of measurements is crucial. Best correlations with infarct volume were found for the 2-to-4-day interval after stroke.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted Magnetic Resonance Imaging and Neurobiochemical Markers After Aortic Valve Replacement

Stolz

Gerriets

Kluge

et al. 2004

Stroke

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“…In another study, a group of authors also reported high correlation between the serum NSE to the volume of lesion within 24 hours of acute ischemic stroke onset( r=0.62, p<0.001). [7] A group of Indian authors also reported a positive significant correlation between concentration of NSE on day 1 and infarct volume as determined by CT scan in acute ischemic stroke patients(r=0.955, p<0.001). [8] In another study also, a significant positive correlation of serum NSE level to the CT scan volume of lesion( r=+0.993; p<0.001) has been reported in acute ischemic stroke patsients within 24-48 hours of stroke onset.…”

Section: Discussionmentioning

confidence: 97%

Role of serum Neuron Specific Enolase in differentiating the side of brain lesion in acute ischemic stroke

Baidya¹,

Tiwari

Usman

2015

Int Jour of Biomed Res

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Objectives: The aim of this study is to see the role of serum NSE (Neuron Specific Enolase) as a neuronal damage marker and in differentiating the side of brain lesion in acute ischemic stroke patients. Methods: A total of 35 acute ischemic stroke patients (clinically and radiologically confirmed) irrespective of age and sex, admitted in Emergency Unit, Medicine Department within 24 hours of stroke onset were included in this study. Plain CT scan or MRI brain was done for all these patients on admission and after 48 hours to confirm the diagnosis and the side of the lesion in brain. Serum NSE was estimated by using NSE Human ELISA Kit, in the Department of Physiology. Results: In this study, serum NSE bears a positive significant correlation to the infarct volume in brain (r=0.783, p<0.001) and to the National Institute of Health Stroke Scale (NIHSS) (r=0.538, p=0.001). However, there is no significance difference between the serum NSE in right hemispheric brain lesion compared to left hemispheric brain lesion (p=0.596). Conclusions: Serum NSE within 24 hours of stroke onset can reflect the volume of brain lesion and severity of acute stroke but cannot differentiate the side of brain lesion in these patients.

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“…Thus high levels of NSE in serum/CSF often indicate neuronal damage in case of neurological disorders such as stroke [16]. Some studies have shown a positive correlation between NSE levels and infarct volume in patients of AIS [17,18]. S100 ββ is a calciumbinding protein expressed mainly in human astroglial cells.…”

Section: Discussionmentioning

confidence: 99%

Impact of Admission Time on Treatment and Outcome of Stroke in Patients Admitted to Tertiary Care Hospital: A Pilot Study from Central India

Nayak

Husain

Lande

et al. 2015

JCDR

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Prediction of Early Clinical Severity and Extent of Neuronal Damage in Anterior-Circulation Infarction Using the Initial Serum Neuron-Specific Enolase Level

Abstract: The initial serum NSE level is a reliable predictor for the extent of neuronal damage and the severity of clinical neurological deficits in acute anterior-circulation infarction.

Cited by 64 publications

References 33 publications

Diffusion-Weighted Magnetic Resonance Imaging and Neurobiochemical Markers After Aortic Valve Replacement

Diffusion-Weighted Magnetic Resonance Imaging and Neurobiochemical Markers After Aortic Valve Replacement

Role of serum Neuron Specific Enolase in differentiating the side of brain lesion in acute ischemic stroke

Impact of Admission Time on Treatment and Outcome of Stroke in Patients Admitted to Tertiary Care Hospital: A Pilot Study from Central India

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