Prediction of electronic and vibrational properties of poly (hexamethylene biguanide) hydrochloride: A combined theoretical and experimental investigation

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

“…This accounts for the chemical stability of PHMB, with the characteristics of insulator materials. In this regard, Rodrigues et al 27 had similar observations to Celik and Tanıs 30 and reached the same conclusion.…”

“…2b). 27 The first imino group can generally be protonated at pH ≈ 11 and the other one at about 2.5, which means PHMB is in the monoprotonated form at a physiological pH. 28 Also, PHMB was suggested to be used as a chelating agent to interact with metallic ions.…”

Screening-enhanced effect enables poly(hexamethylene biguanide) hydrochloride to effectively overcome charge screening limitations

“…Due to the unique molecular structural properties (e.g., the rigid active biguanide moieties and flexible alkyl linking groups), PHMB exhibits self-folding behavior enthalpically driven by the like-charge pairing of the biguanide units, making the adsorption reaction a fast kinetic process 8 . The significant HOMO-LUMO energy gap of PHMB also favors its stable chemical skeleton and thermal stability 9 . Also, the biguanide group has three tautomeric resonance forms, which implies that biguanide-bearing cationic polyelectrolytes, including PHMB, have high proton mobility and pH-tolerant properties owing to the delocalization of charges [10][11][12] .…”