In this study, mechanical properties and hand values are predicted from the parameters of weave structures. To promote the design of woven fabrics, we can define the crossing-over firmness factor (CFF) and the floating yarn factor (FYF) as the parameters of the weave structures for predicting mechanical properties and hand values. Both the CFF and FYF are related to some mechanical parameters and primary hand. Multiple regression equations of mechanical parameters and hand values are derived from those parameters of weave structures, and the predicted values almost exactly agree with the measured values from the KES-FB system.