Prediction of febrile seizures in siblings: a practical approach

Esch, Adrianus van; Steyerberg, Ewout W.; Duijn, C.M. van; Offringa, Martin; Derksen‐Lubsen, Gerarda; Steensel-Moll, H A van

doi:10.1007/s004310050824

Cited by 22 publications

(13 citation statements)

References 16 publications

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“…Despite the common belief that the rise in temperature per se is more important for the development of FS than the actual temperature achieved, there is no evidence to support that view [14,55]. Fever in children with FS is typically higher than in controls with similar fever-related illnesses, and seizures usually develop in the first 24 hours of the illness [91]. Measurements of fever have methodological problems because some reports in the literature refer to axillary temperature and some to rectal temperature, and because FS does not always occur at the peak level of fever or at the onset of fever [91].…”

Section: Fevermentioning

confidence: 84%

“…Fever in children with FS is typically higher than in controls with similar fever-related illnesses, and seizures usually develop in the first 24 hours of the illness [91]. Measurements of fever have methodological problems because some reports in the literature refer to axillary temperature and some to rectal temperature, and because FS does not always occur at the peak level of fever or at the onset of fever [91]. Although the average level of fever in children with FS is high (39.8°C), the seizure itself is the first sign of febrile illness in 25-50% of all cases of FS [30].…”

Section: Fevermentioning

confidence: 98%

“…A positive family history of FS (in first-degree relatives) is probably the most consistently identified risk factor for developing FS, and the risk increases with the number of relatives who have this history [91]. The genetic component of FS is complex, however, and the risk varies greatly between families who may have similar histories of the condition [17,32,66,89].…”

Section: Geneticsmentioning

confidence: 99%

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Assessment of febrile seizures in children

2007

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Febrile seizures are the most common form of childhood seizures, affecting 2-5% of all children and usually appearing between 3 months and 5 years of age. Despite its predominantly benign nature, a febrile seizure (FS) is a terrifying experience for most parents. The condition is perhaps one of the most prevalent causes of admittance to pediatric emergency wards worldwide. FS, defined as either simple or complex, may be provoked by any febrile bacterial or (more usually) viral illness. No specific level of fever is required to diagnose FS. It is essential to exclude underlying meningitis in all children with FS, either clinically or, if any doubt remains, by lumbar puncture. There is no evidence, however, to support routine lumbar puncture in all children admitted with simple FS, especially when typical clinical signs of meningitis are lacking. The risk of epilepsy following FS is 1-6%. The association, however small, between FS and epilepsy may demonstrate a genetic link between FS and epilepsy rather than a cause and effect relationship. The effectiveness of prophylactic treatment with medication remains controversial. There is no evidence of the effectiveness of antipyretics in preventing future FS. Prophylactic use of paracetamol, ibuprofen or a combination of both in FS, is thus a questionable practice. There is reason to believe that children who have experienced a simple FS are over-investigated and over-treated. This review aims to provide physicians with adequate knowledge to make rational assessments of children with febrile seizures.

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Section: Fevermentioning

confidence: 84%

Section: Fevermentioning

confidence: 98%

Section: Geneticsmentioning

confidence: 99%

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Assessment of febrile seizures in children

2007

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“…In cohorts of children with FS, the risk that siblings will have an FS is 10-45%. 27 Many studies have also found that the risk may be increased by an underlying brain disorder. Premature birth, delayed discharge from the neonatal intensive care unit, and developmental delay are potential markers for suboptimal brain function, but there is conflicting evidence definitively linking these factors and FS, 16 21 24 28-31 which may in part reflect whether the study was hospital or community based.…”

Section: Risk Factorsmentioning

confidence: 99%

Febrile seizures: an update

Waruiru

Appleton

2004

Archives of Disease in Childhood

323

239

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“…The most commonly defined risk factor is family history in first degree family members. Cohort studies in patients with febrile convulsion; risk of siblings was determined as 10-45% (11). Cognitive dysfunction, psychomotor retardation, behavioral problems, pica, breath holding spells, restless leg syndrome, and thrombosis could be associated with iron deficiency.…”

Section: Introductionmentioning

confidence: 99%

Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency

Gencer¹,

Kafadar²,

Köse³

et al. 2016

JAREM

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Objective: Febrile convulsion (FC) is the most common type of seizure in children. Its incidence is 2-5%. Iron and zinc, as a major element of some enzymes, play an important role in the central nervous system (CNS) and can affect some inhibitory mechanisms of CNS. The aim of this study is to evaluate the association of FC with iron deficiency anemia and zinc deficiency and the relationship of FC with its pathogenesis. Methods:We prospectively evaluated the demographic and clinical characteristics of FC in 57 children aged 3-60 months who presented to the pediatric emergency department as the case group and 25 healthy children who presented to outpatient clinics as the control group in Şişli Hamidiye Etfal Training and Research Hospital, a tertiary state hospital in İstanbul, between January 2013 and July 2013. Anemia was defined as a hemoglobin (Hb) level of <11 g/dL. The serum zinc levels were determined by atomic absorption spectrophotometry.Results: The male to female ratio was 1.71/1. The mean age at the first seizure was 21.6±11.8 months. The most common cause of FC was upper respiratory tract infection (84.2%). Twenty (35.1%) patients had a family history of FC and 8 (14%) had a family history of epilepsy. The most common seizure type was generalized tonic-clonic seizures (78.9%). There was no statistically significant difference between the case and control groups in the anemia ratio, Hb level, Htc, MCV, RDW, RBC count, platelet count, TIBC, and ferritin level. There were statistically significant lower rates of mean serum zinc levels and hypozincemia in the case group.Conclusion: There was no statistically difference between FC and anemia. The serum zinc levels were found to be lower in patients with FC. The relationship between low zinc levels and convulsion is not understood whether it is a cause or result. It can emphasize the hypothesis that there is a relation between serum zinc levels and febrile convulsion in children. (JAREM 2016; 6: 94-7)

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Prediction of febrile seizures in siblings: a practical approach

Abstract: The cumulative risk of FS in siblings of children with FS is increased. The age attained risk of FS can be estimated using a practical model incorporating three readily available risk factors.

Cited by 22 publications

References 16 publications

Assessment of febrile seizures in children

Assessment of febrile seizures in children

Febrile seizures: an update

Relationship of Febrile Convulsion with Iron Deficiency Anemia and Zinc Deficiency

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