This paper assessed the spatio-temporal variations of soil salinity in Gusau Local Government Area of Zamfara State. Modis and Landsat images of three epochs were used to examine the effective area from 2000 to 2020.The study employed an index-based approach of RS and GIS to monitor the variations and changes in salinity. NDVI from Modis data with a threshold of -1 to 1 was used to measure salinity based on crop response to various degrees of salinity, while NDSI was used to measure salinity directly from the surface salt reflectance using Landsat images. The NDVI was classified into three classes; bare surfaces from (-0.46 to 0.2), sparse vegetation (0.2 to 0.5) and dense vegetation (0.5 to 0.7). The result revealed that shows three salinity classes low (0.3 to 0.5), moderate (0.5 to 0.7) and high salinity (0.7 to 1). In addition, it showed a positive trend (an increase of 0.0013) in the vegetation of the study period, while that of the salinity has a negative trend (decrease of -0.0014) over the study period. The result revealed that the area with a bare surface has high salinity compared to the other classes in the study area. The study recommends the enhancements of models in the prediction and monitoring of further salinity implications.