Prediction of gastric cancer lymph node status by sentinel lymph node biopsy and the Maruyama computer model

Gretschel, Stephan; Bembenek, A.; Ulmer, C.; Hünerbein, M.; Markwardt, J.; Schneider, Ulrike; Schlag, P. M.

doi:10.1016/j.ejso.2004.11.014

Cited by 31 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FNR was calculated using the definition outlined by McMasters et al [13]: (number of false negatives)/(number of true positives). We felt that the FNR was the most important factor when considering the applicability of SLN identification, because a false-negative result (when an SLN was free of tumor cells but other nonSLNs revealed metastases) could lead to an incorrect decision about treatment [13,14].…”

Section: Discussionmentioning

confidence: 99%

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

et al. 2012

View full text Add to dashboard Cite

Background In gastric cancer, the utility of sentinel lymph node (SLN) biopsy has not been established. SLN may be a good predictor of the pathological status of other lymph nodes and thus the necessity for more extensive surgery or lymph node dissection. We aimed to identify and synthesize findings on the performance of SLN biopsies in gastric cancer. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from 1998 to 2009. Titles and abstracts were independently rated for relevance by a minimum of two reviewers. Techniques, detection rates, accuracy, sensitivity, specificity, and false-negative rates (FNRs) were analyzed. Analysis was performed based on the FNR. Results Twenty-six articles met our inclusion criteria. SLN detection using the dye method (DM) was reviewed in 18 studies, the radiocolloid method (RM) was used in 12 studies, and both dye and radiocolloid methods (DUAL) were used in 5 studies. The DM had an overall calculated FNR of 34.7% (95% confidence interval [CI] 21.2, 48.1). The RM had an overall calculated FNR of 18.5% (95% CI 9.1, 28.0). DUAL had an overall calculated FNR of 13.1% (95% CI -0.9, 27.2). Conclusion Application of the SLN technique may be practical for early gastric cancer. The use of DUAL for identifying SLN may yield a lower FNR than either method alone, although statistical significance was not met.

show abstract

Section: Discussionmentioning

confidence: 99%

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Low sensitivity percentages of less then 90% were observed in 13/21 studies. (10)(11)(12)14,17,(20)(21)(22)(23)(24)(25)(26) In two of M A N U S C R I P T Subgroup analyses according to detection method (see Table 4) showed better discriminative power for the radiocolloid detection method then dye methods, irrespective of the application method of the dye. However, a tendency towards the best discriminative power was seen for the combination of dye and radiocolloid.…”

Section: Resultsmentioning

confidence: 99%

“…All studies using a radiocolloid injected the detection substance peritumorally in the submucosal layer of the stomach via endoscopic route one day preoperatively. In nine out of 17 an endoscope was used in to inject the dye in the submucosal layer (10)(11)(12)15,18,20,22,23,26), while 8/17 injected the detection substance peritumorally in the subserosal layer during laparotomy. (7,9,13,14,19,23,24) In one study the detection effect of indocyanine green was enhanced by using infrared ray electronic endoscopy (IREE).…”

Section: Resultsmentioning

confidence: 99%

“…The selection and analysis of studies has been performed independently by three investigators (DJL, HWS, RLAL, AED). Studies available for analysis (ref (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)) were subjected to a quality control using the QUADAS tool. (27) Quality was considered to be good for two studies, moderate for 12 studies and poor for four studies.…”

Section: Systematic Searchmentioning

confidence: 99%

See 1 more Smart Citation

Sentinel lymph node biopsy to direct treatment in gastric cancer. A systematic review of the literature

Lips¹,

Schutte²,

Linden³

et al. 2011

European Journal of Surgical Oncology (EJSO)

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. analyses showed that the combination of dye and radiocolloid detection substances is the best method for sentinel lymph node detection in early gastric cancer. However, the precise method of sentinel lymph node biopsy in EGC has to be determined further. Large, randomized series should be initiated in Europe to address this issue. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT

show abstract

“…A single comparative study (SNB vs. MCP) from Germany has proven SNB to be of higher clinical relevance than the Maruyama computer model for predicting nodal status and compartimental involvement [25].…”

Section: Discussionmentioning

confidence: 99%

Prospective, comparative study for the evaluation of lymph node involvement in gastric cancer: Maruyama computer program versus sentinel lymph node biopsy

et al. 2012

View full text Add to dashboard Cite

Background Stage-adapted surgery guarantees the best outcome for patients with gastric cancer. Successful identification of lymph node involvement may help to reduce the number of extended lymphadenectomies. Preoperative diagnostic tools have low sensitivity and specificity for determining lymph node involvement. Evaluation of sentinel lymph nodes (SLNs) intraoperatively has good results, while the accuracy of the Maruyama computer program (MCP) is controversial. Methods We investigated 40 patients by the Maruyama computer model and labeled lymph nodes with blue dye for SLN mapping. To compare the probability calculations by MCP and the results of SLN mapping, we had to define a cutoff level; we did this using receiver-operating characteristics analysis. Sentinel lymph nodes were examined in frozen sections intraoperatively and by standard hematoxylin and eosin staining postoperatively. Results A total of 795 lymph nodes were removed and examined. The Maruyama computer model had a sensitivity of 91.3 %, specificity of 64 %, and accuracy of 80 % by the best cutoff point. The false-negative rate was 8.7 %. The sensitivity of SLN mapping was 95.7 %, the falsenegative rate was 4.3 %, and the specificity was 100 %. The accuracy of SLN mapping was 97.4 %. Only the sensitivity of MCP and SLN biopsy was proven equivalent. Conclusions Our results suggest that intraoperative SLN examination is superior to preoperative estimation with the MCP. Correct definition of lymph node involvement helps in planning the best stage-adapted surgery in gastric cancer.

show abstract

Prediction of gastric cancer lymph node status by sentinel lymph node biopsy and the Maruyama computer model

Cited by 31 publications

References 27 publications

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

What is the accuracy of sentinel lymph node biopsy for gastric cancer? A systematic review

Sentinel lymph node biopsy to direct treatment in gastric cancer. A systematic review of the literature

Prospective, comparative study for the evaluation of lymph node involvement in gastric cancer: Maruyama computer program versus sentinel lymph node biopsy

Contact Info

Product

Resources

About