Prediction of GFR in liver transplant candidates

Measured GFR as a Confirmatory Test for Estimated GFR

“…38 Studies comparing urinary and plasma clearance of either iothalamate or iohexol show high agreement, although some studies showed that plasma clearance slightly overestimates urinary clearance at lower levels of GFR (Table 5). 17,34 In studies of repeated measurements of plasma clearance of iothalamate or iohexol, the coefficient of variation ranged from 5.6 to 11.5%, 37,39,42,43 similar to the variation observed with urinary clearance reported above.…”

Performance of iohexol determination in serum and urine by HPLC: Validation, risk and uncertainty assessment

“…Moreover, iohexol determination in urine has been poorly studied. Now, on particular conditions and especially in patients with ascite or interstitial oedema, the accurate measure of the urinary clearance is of importance and better than the plasma clearance [29]. Moreover, the reproducibility of GFR measurement is relatively high (around 10%).…”

How Measuring Glomerular Filtration Rate? Comparison of Reference Methods

“…The relatively worst results obtained by Erley are explained by the patients included (Erley et al, 2001). Actually, the patients hospitalized in intensive care are prone to develop edema and, in this situation, plasmatic clearances are not accurate, whatever the marker (Skluzacek et al, 2003). The study published by Gaspari demonstrated a good performance of iohexol plasma clearance compared to inulin but the number of samples was high and these samples were drawn lately (after 10h) (Gaspari et al, 1995 Table 5.…”