2022
DOI: 10.1101/2022.08.04.502886
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Prediction of Golgi Polarity in Collectively Migrating Epithelial Cells Using Graph Neural Network

Abstract: In the stationary epithelium, the Golgi apparatus assumes an apical position, above the cell nucleus. However, during wound healing and morphogenesis, as the epithelial cells starts migrating, it relocalizes closer to the basal plane. On this plane, the position of Golgi with respect to the cell nucleus defines the organizational polarity of a migrating epithelial cell, which is crucial for an efficient collective migration. Yet, factors influencing the Golgi polarity remain elusive. Here we constructed a grap… Show more

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