Prediction of Hepatic Fibrosis Progression Rate in Chronic Hepatitis C on the Basis of Clinical and Genetic Signs

Patterns of Liver Injury and Anxiety Degree in Pediatric Patients With Chronic Viral Hepatitis B and C as Predictors of Liver Fibrosis Prognosis

“…Scientists conduct researches of assessing the rate of formation of liver fibrosis induced by HBV-and HCVviruses and features of forecasting its development, however, mainly in the adult population [6,7].…”

“…However, in patients who were infected during the first years of life, the progression of CVHC is faster [3].According to WHO reports, about 2.2-3.0% of the world's population (130-170 million people) suffer from CVHC [4]. CVHC in children is mostly asymptomatic, in 4-6% it has a progressive course with the development of fibrosis and cirrhosis of the liver [5].Scientists conduct researches of assessing the rate of formation of liver fibrosis induced by HBV-and HCVviruses and features of forecasting its development, however, mainly in the adult population [6,7].Along with that, in patients with increasing age and progression of liver fibrosis, the manifestations of clinical symptoms of asthenic, astheno-vegetative, hemorrhagic and dyspeptic syndromes, lymphadenopathy and splenomegaly syndrome, extrahepatic manifestations, as well as psycho-emotional, somatopsychic and somatoform disorders are increasing.At the same time, the prevalence of HCV infection in respondents with mental and psychiatric disorders varies from 8% to 31%, which is significantly higher than…”