Prediction of high ovarian response to controlled ovarian hyperstimulation: anti-Müllerian hormone versus small antral follicle count (2–6 mm)

Aflatoonian, Abbas; Oskouian, Homa; Ahmadi, Shahnaz; Oskouian, Leila

doi:10.1007/s10815-009-9319-5

Cited by 61 publications

(45 citation statements)

References 40 publications

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“…10,11 From the present study, we conclude that age and AMH have negative correlation (r-0.266) ( Figure 1). …”

Section: -40supporting

confidence: 54%

“…Patients were studied with respect to total number of oocytes, number of mature oocytes, duration of stimulation, total dose of gonadotropins, peak E2 levels, number of embryos and Grade A embryos. According to number of oocytes retreived, patients were divided into poor responders (<3 oocytes) normal responders (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and hyperresponders (>20).…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of ovarian response prediction according to age and serum AMH levels in IVF cycles: a retrospective analysis

Pillai¹,

Mahabalshetti

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThe accurate prediction of the response to ovarian stimulation is a valuable diagnostic step in the process of assisted reproduction. Increasing female literacy and employment have resulted in a clear rise in the age at which women conceive. As fertility starts to decline with advancing age more and more number of women are facing the problem of infertility and are seeking medical attention to overcome this problem. This decline in fertility is predominantly due to reduced ovarian reserve with increasing age. It has been shown that the rate of ovarian reserve decline varies considerably between individual women making it a challenge to design tests that estimate an individual's reproductive lifespan at a given age.1 A reliable marker for the age at which subfertility will occur would have great potential value as predictor of future reproductive lifespan. The ideal ABSTRACT Background: Increasing female literacy and employment have resulted in a clear rise in the age at which women conceive. As fertility starts to decline with advancing age more and more number of women are facing the problem of infertility and are seeking medical attention to overcome this problem. A number of ovarian reserve tests were developed to overcome this problem. Recent studies indicate that anti mullerian hormone is a promising marker for predicting ovarian reserve and pregnancy outcome. Methods: A retrospective study conducted at SAMAD IVF hospital, Trivandrum, Kerala. The aim of this study was to assess the influence of age on Anti-Mullerian Hormone (AMH) in ART (assisted reproductive technology) program outcomes and determine whether AMH levels and age predict the availability of total oocytes and MII oocytes retrieved and good quality of embryos. Ninety-six subjects in the age group of 25 to 40 years were included and underwent controlled ovarian stimulation (COS) and later intracytoplasmic sperm injection (ICSI) was performed. Results: In present study, it is seen that age and AMH (anti-mullerian hormone) have negative correlation. In accordance to AMH, total number of oocytes retrieved, MII oocytes, total number of embryos and grade A embryos were higher in AMH group (>5ng/ml). Total embryos for cryopreservation were lower in age group of 31-35yrs and 36-40yrs with least AMH value as compared to younger age group, good quality of embryos was higher in age group of 25-30yrs with 1.5-5 and >5 AMH group. Conclusions: Serum AMH is an important ovarian reserve test to predict response in ART cycles. Age is an independent marker in terms of quality of oocytes retrieved. We conclude that age and AMH have negative correlation. Hence, AMH can predict number of oocytes retrieved but age predicts quality of oocytes and embryos.

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“…10,11 From the present study, we conclude that age and AMH have negative correlation (r-0.266) ( Figure 1). …”

Section: -40supporting

confidence: 54%

Section: Methodsmentioning

confidence: 99%

Evaluation of ovarian response prediction according to age and serum AMH levels in IVF cycles: a retrospective analysis

Pillai¹,

Mahabalshetti

2017

Int J Reprod Contracept Obstet Gynecol

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“…In addition, the statistical model developed evidenced that the decrease in plasma AMH concentrations with age is more marked in the low AFC group compared with the high one. In this regard, AFC and AMH are widely used to predict ovarian reserve and ovarian response to controlled stimulation with exogenous gonadotropins for assisted reproductive technologies (ARTs) treatments (La Marca et al 2007, Aflatoonian et al 2009, Fleming et al 2015; moreover, a better prediction of ovarian responsiveness is achieved when using AMH, AFC, and age together (Brodin et al 2015). Taken together, these results immediately suggest that high AFC and AMH concentrations in the early prepubertal period may represent a precocious marker of the ovarian reserve of a given individual, considering that the quantity and quality of non-growing follicles in the ovary is positively associated with the number of growing follicles, plasma AMH concentrations, and reproductive life-span .…”

Section: Discussionmentioning

confidence: 99%

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Torres-Rovira¹,

Succu²,

Pasciu³

et al. 2016

Reproduction

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The importance of postnatal pituitary activation as regards female reproductive development is not yet understood. By taking advantage of the experimental model developed in a previous study, i.e. ewe lambs expressing markedly different ovarian phenotypes at 50 days of age, we designed this study to determine whether differences found in ovarian status during the early prepubertal period are due to different patterns of postnatal pituitary activation, and to assess whether these differences have long lasting effects on subsequent reproductive performance. Results showed that ewe lambs with high antral follicle count (AFC) at 50 days of age had significantly lower plasma FSH concentrations and higher anti-Mullerian hormone (AMH) concentrations during the first 9 weeks of age compared with low AFC ewe lambs (P!0.0001). With a longitudinal experiment we showed that a high AFC in the early prepubertal period is associated with consistently higher AMH concentrations and numbers of antral follicles up to the postpubertal period, and with higher pregnancy rates in the first breeding season. In addition, the effect of age in decreasing AMH concentrations was more marked in the low AFC group. Results of the present study demonstrate that ewe lambs undergo different patterns of postnatal pituitary activation. A high AFC at 50 days of age indicates an advanced phase of ovarian maturation, which was accompanied by constantly higher AMH concentrations up to the postpubertal period, a greater ovarian response to FSH stimulation and by higher pregnancy rates at first mating, as compared with the low AFC group.

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“…This was confirmed by another study that showed that small AFC (2-6 mm) and AMH are equally accurate predictors of ovarian response to controlled ovarian hyperstimulation (17). In addition to being a good marker for the quantity of follicles, AMH is also suggestive of the quality of the remaining oocytes (18).…”

Section: Assisted Reproductionmentioning

confidence: 66%

Anti-Müllerian Hormone (Amh) in Gynecological Endocrinology

2017

ARC Journal of Gynecology and Obstetrics

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Prediction of high ovarian response to controlled ovarian hyperstimulation: anti-Müllerian hormone versus small antral follicle count (2–6 mm)

Cited by 61 publications

References 40 publications

Evaluation of ovarian response prediction according to age and serum AMH levels in IVF cycles: a retrospective analysis

Evaluation of ovarian response prediction according to age and serum AMH levels in IVF cycles: a retrospective analysis

Postnatal pituitary and follicular activation: a revisited hypothesis in a sheep model

Anti-Müllerian Hormone (Amh) in Gynecological Endocrinology

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