Prediction of hip and hand fractures in older persons with or without a diagnosis of periodontitis

Persson, G. Rutger; Berglund, Johan; Persson, Rutger; Renvert, Stefan

doi:10.1016/j.bone.2010.09.237

Cited by 22 publications

(24 citation statements)

References 38 publications

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“…Diseases such as diabetes mellitus, cardiovascular diseases (CVDs), and osteoporosis have been associated with periodontitis in older individuals 26‐31 . A risk for early mortality in young individuals with periodontitis has also been identified 32 …”

Section: Methodsmentioning

confidence: 99%

Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care

Renvert

Persson

2013

Journal of Periodontology

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Section: Methodsmentioning

confidence: 99%

Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care

Renvert

Persson

2013

Journal of Periodontology

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“…Currently, it is still unclear whether there is an inverse interaction of periodontal disease to systemic bone remodeling [9]. A large prospective cohort study by Persson et al [45] reported that osteoporotic patients with periodontitis have a higher risk for hip/hand fracture. More recently, experimental periodontitis aggravated systemic ovariectomy -induced bone loss [46••].…”

Section: Shared Risk Factorsmentioning

confidence: 99%

“…Recent association studies have chosen to investigate pathological fractures relative to the status of periodontal disease, and the presence of periodontitis is associated with an increased risk of fractures [90, 91]. Another more convincing prospective study showed that elderly patients with generalized severe periodontitis have an odds ratio (OR) of hip/hand fracture of 1.8:1 and after adjustment for age, the OR increased to 12 [45]. Experimental periodontitis was found to aggravate systemic ovariectomy-induced bone loss [46••].…”

Section: Interdisciplinary Management Of Osteoporosis and Periodontitismentioning

confidence: 99%

Osteoporosis and Periodontitis

Wang

McCauley

2016

Curr Osteoporos Rep

158

124

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Osteoporosis and periodontitis are both diseases characterized by bone resorption. Osteoporosis features systemic degenerative bone loss that leads to loss of skeletal cancellous microstructure and subsequent fracture, whereas periodontitis involves local inflammatory bone loss, following an infectious breach of the alveolar cortical bone, and it may result in tooth loss. Most cross-sectional studies have confirmed the association of osteoporosis and periodontitis primarily on radiographic measurements and to a lesser degree on clinical parameters. Multiple shared risk factors include age, genetics, hormonal change, smoking, as well as calcium and vitamin D deficiency. Both diseases could also be risk factors for each other and have a mutual impact that requires concomitant management. Suggested mechanisms underlying the linkage are disruption of the homeostasis concerning bone remodeling, hormonal balance, and inflammation resolution. A mutual interventional approach is emerging with complex treatment interactions. Prevention and management of both diseases require interdisciplinary approaches and warrants future well-controlled longitudinal and interventional studies for evidence-based clinical guidelines.

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“…Despite these efforts, the ability to predict the incidence of osteoporotic fractures based on jawbone measurements has not been accomplished [25–27]. This is possibly due to technical limitations with measuring jaw BMD.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Alveolar Bone Mineral Density as a Predictor of Lumbar Fracture Probability

et al. 2013

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IntroductionOsteoporosis and tooth loss have been linked with advancing age, but no clear relationship between these conditions has been proven. Several studies of bone mineral density measurements of the jaw and spine have shown similarities in their rate of age-related deterioration. Thus, measurements of jawbone density may predict lumbar vertebral bone density. Using jawbone density as a proxy marker would circumvent the need for lumbar bone measurements and facilitate prediction of osteoporotic spinal fracture susceptibility at dental clinics. We aimed to characterize the correlation between bone density in the jaw and spine and the incidence of osteoporotic spinal fractures.MethodsWe used computerized radiogrammetry to measure alveolar bone mineral density (al-BMD) and dual-energy X-ray absorptiometry to measure lumbar bone mineral density (L-BMD). L-BMD and al-BMD in 30 female patients (average age: 59 ± 5 years) were correlated with various patient attributes. Statistical analysis included area under the curve (AUC) and probability of asymptomatic significance (PAS) in a receiver operating characteristic curve. The predictive strength of L-BMD T-scores (L-BMD[T]) and al-BMD measurements for fracture occurrence was then compared using multivariate analysis with category weight scoring.ResultsL-BMD and al-BMD were significantly correlated with age, years since menopause, and alveolar bone thickness. Both were also negatively correlated with fracture incidence. Category weight scores were −0.275 for a L-BMD(T) <80%; +0.183 for a L-BMD(T) ≥80%; −0.860 for al-BMD <84.9 (brightness); and +0.860 for al-BMD ≥84.9. AUC and PAS analyses suggested that al-BMD had a higher association with fracture occurrence than L-BMD.ConclusionsOur results suggest the possible association between al-BMD and vertebral fracture risk. Assessment of alveolar bone density may be useful in patients receiving routine dental exams to monitor the clinical picture and the potential course of osteoporosis in patients who may be at a higher risk of developing osteoporosis.

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Prediction of hip and hand fractures in older persons with or without a diagnosis of periodontitis

Cited by 22 publications

References 38 publications

Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care

Tooth Loss and Periodontitis in Older Individuals: Results From the Swedish National Study on Aging and Care

Osteoporosis and Periodontitis

Assessment of Alveolar Bone Mineral Density as a Predictor of Lumbar Fracture Probability

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