Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women

Jayaprakasan, Kannamannadiar; Chan, Y.; Islam, Rumana; Haoula, Zeina; Hopkisson, James; Coomarasamy, Arri; Raine‐Fenning, Nick

doi:10.1016/j.fertnstert.2012.05.042

Cited by 90 publications

(61 citation statements)

References 46 publications

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“…Reports examining the correlation with clinical pregnancy rate and live birth rate, however, are more variable (Chang et al, 1998a(Chang et al, , 1998bHsu et al, 2011;Jayaprakasan et al, 2012;Lukaszuk et al, 2014), and AFC has not been shown to be predictive of embryo quality (Chang et al, 1998a(Chang et al, , 1998bHsu et al, 2011;Jayaprakasan et al, 2012). It has also been suggested that determination of AFC may be helpful in identifying an appropriate stimulation protocol (Hsu et al, 2011).…”

Section: Afc: the Evidence As A Predictive Methodsmentioning

confidence: 99%

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Fleming¹,

Seifer

Frattarelli³

et al. 2015

Reproductive BioMedicine Online

234

148

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Section: Afc: the Evidence As A Predictive Methodsmentioning

confidence: 99%

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Fleming¹,

Seifer

Frattarelli³

et al. 2015

Reproductive BioMedicine Online

234

148

View full text Add to dashboard Cite

“…We anticipated the practical difficulty of conducting a robust large trial in women with diminished ovarian reserve due to potential limitations in recruiting a large number of eligible subjects and therefore have set out to do a pilot trial (DITTO-DHEA Intervention To Treat Ovarian ageing-trial) so that we could evaluate the feasibility of conducting a large multicentre study as well. The objective of this study was to determine the effect of DHEA on the ovarian response during controlled ovarian stimulation and the developmental competence of oocytes (oocyte quality) by using molecular and clinical parameters in women predicted to have poor ovarian reserve or ovarian ageing, defined by using reported AFC and AMH thresholds (36,37).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): A proof of principle double blinded randomized placebo controlled trial

Narkwichean

Maalouf

Baumgarten

et al. 2017

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibility of conducting a large trial is also assessed by evaluating the recruitment rates and compliance of the recruited participants with DHEA/placebo intake and follow-up rates. Study design:A single centre, double blinded, placebo controlled, randomized trial was performed over two years with 60 women undergoing in-vitro fertilisation (IVF). Subjects were randomized, based on a computer-generated pseudo-random code to receive either DHEA or placebo with both capsules having similar colour, size and appearance. 60 women with poor OR based on antral follicle count or anti-Mullerian hormone thresholds undergoing IVF were recruited. They were randomised to receive DHEA 75 mg/day or placebo for at-least 12 weeks before starting ovarian stimulation. They had long protocol using hMG 300 IU/day. Data analysed by "intention to treat". Ovarian response, live birth rates and molecular markers of oocyte quality were compared between the study and control groups. Results:The recruitment rate was 39% (60/154). A total of 52 participants (27 versus 25 in the study and placebo groups) were included in the final analysis after excluding eight. While the mean (standard deviation) DHEA levels were similar at recruitment (9.4 (5) versus 7.5 (2.4) ng/ml; P = 0.1), the DHEA levels at pre-stimulation were higher in the study group than in the controls (16.3 (5.8) versus 11.1 (4.5) ng/ml; P < 0.01). The number (median, range) of oocytes retrieved (4, 0-18 versus 4, 0-15 respectively; P = 0.54) and live birth rates (7/27, 26% versus 8/25, 32% respectively; RR (95% CI): 0.74 (0.22-2.48) and mRNA expression of developmental biomarkers in granulosa and cumulus cells were similar between the groups. Conclusion:Pre-treatment DHEA supplementation, albeit statistical power in this study is low, did not improve the response to controlled ovarian hyperstimulation or oocyte quality or live birth rates during IVF treatment with long protocol in women predicted to have poor OR.

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“…The correlation of antral follicle counts with poor response in IVF has been several studies 74,76,77 . In a recent study investigating the role of AFC in IVF outcome prediction, it has been shown that antral follicle count was predictive of ovarian response, with a 67% likelihood of poor ovarian response for AFC 4, also there was a significant linear relationship between AFC, age and live birth which is much more marked for AFC 78 . A study comparing the effectiveness of basal and CC induced inhibin-B and FSH, ovarian volume and antral follicle counts to predict the outcome of IVF cycles, reported that ovarian volume was the best parameter to predict poor ovarian response to COH(Controlled Ovarian Hyperstimulation), whereas age and antral follicle counts were found to be better than the other test with respect to predicting pregnancy success 74 .…”

Section: Antral Follicle Counts (Afc)mentioning

confidence: 98%

Assessment of Ovarian Reserve in Infertile Patients

Begum¹,

Shaha

Mahbuba³

et al. 2017

Anwer Khan Mod Med Coll J

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Reduced ovarian reserve is a condition characterized by a reduced competence of the ovary to produce oocyte due to advanced age or congenital, medical surgical and idiopathic causes. Age is considered to be the principal factor in determining the reduction of ovarian reserve, especially in woman over 40 years of age, but it's well known that a premature reduction of ovarian reserve can also occur in young patients. Management of patients with diminished ovarian reserve is challenging for fertility experts and frequently the only option to conceive is represented by assisted reproduction technologies. Here we reviewed the aetiology, presentation and diagnosis of reduced ovarian reserve in advanced and young aged women and recent advances in the management of infertility in these women.Key Words: Reduced ovarian reserve; Diminished ovarian reserve; Premature ovarian failure ABSTRACT Introduction

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Prediction of in vitro fertilization outcome at different antral follicle count thresholds in a prospective cohort of 1,012 women

Cited by 90 publications

References 46 publications

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Assessing ovarian response: antral follicle count versus anti-Müllerian hormone

Efficacy of Dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): A proof of principle double blinded randomized placebo controlled trial

Assessment of Ovarian Reserve in Infertile Patients

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