Prediction of in vivo hip contact forces during common activities of daily living using a segment-based musculoskeletal model

Amiri, Pouya; Bull, Anthony M. J.

doi:10.3389/fbioe.2022.995279

Cited by 7 publications

(4 citation statements)

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“…Inverse MSK modeling uses the observed kinematics and ground reaction forces to determine the net forces and moments at the joints and uses an optimization method to resolve the muscle force sharing. FreeBody is a segment-based MSK model ( Cleather and Bull, 2015 ) that has been extensively validated for muscle activations using EMG experimental data for bilateral transfemoral amputees ( Toderita et al, 2021 ), unilateral transtibial amputees ( Ding et al, 2023 ), knee joint contact forces for osteoarthritis patients ( Ding et al, 2016 ), and hip joint contact forces also using instrumented implants ( Amiri and Bull, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of muscle recruitment during gait of bilateral transfemoral and through-knee persons with limb loss

Benton

Amiri

Henson

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Due to loss in musculoskeletal capacity, there is an increased burden on the residual limbs of bilateral transfemoral and through-knee persons with limb loss. This reduced capacity is associated with an increased cost of walking that is detrimental to functionality. Compensatory gait strategies are adopted by this population. However, how these strategies relate to specific muscle recruitment is not known. The primary aim of this study is to characterize muscle recruitment during gait of this population. The secondary aim is to assess whether the measured kinematics can be actuated when the endurance of specific muscles is reduced and if this is the case, which alternative muscles facilitate this.Methods: 3D gait data and high-resolution magnetic resonance images were acquired from six bilateral transfemoral and through-knee persons with limb loss. Subject-specific anatomical muscle models were developed for each participant, and a validated musculoskeletal model was used to quantify muscle forces in two conditions: during normal gait (baseline) and when muscles, which were identified as functioning above a “healthy” level at baseline, have a reduced magnitude of maximum force capacity (reduced endurance simulation). To test the hypothesis that there are differences in muscle forces between the baseline trials and the simulations with reduced muscular endurance, a Bonferroni corrected two-way ANOVA with repeated measures was completed between the two states.Results: The baseline analysis showed that the hip flexors experience relatively high muscle activations during gait. The reduced endurance simulation found two scenarios. First, for 5 out of the 12 simulations, the baseline kinematics could not be reproduced with the reduced muscular capacity. Second, for 7 out of 12 cases where the baseline kinematics were achieved, this was possible with compensatory increased activation of some muscles with similar functions (p ≤ 0.003).Discussion: Evidently, due to the loss of the ankle plantar flexors, gait imposes a high demand on the flexor muscle group of the residual limb. This study highlights how the elevated cost of gait in this population manifests in muscle recruitment. To enhance functionality, it is critical to consider the mechanical demand on the hip flexors and to develop rehabilitation interventions accordingly.

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Section: Introductionmentioning

confidence: 99%

Characterization of muscle recruitment during gait of bilateral transfemoral and through-knee persons with limb loss

Benton

Amiri

Henson

et al. 2023

Front. Bioeng. Biotechnol.

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“…As cautioned by Curry et al [46], validation still represents a key limitation of many of the models that have been constructed. The advent of publicly available data sets, including direct measurements of joint contact force during walking (for example, [47,48]), has resulted in substantial improvement in the sophistication of modeling techniques [49], with the construction of patient-specific models, in particular, demonstrating encouraging accuracy for the estimation of the hip or tibiofemoral joint contact forces [50][51][52]. However, the extensive personalization of model parameters remains a time-consuming procedure and typically requires detailed medical imaging data that are not routinely available [53].…”

Section: Bonementioning

confidence: 99%

The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques

Wearing,

Hooper,

Langton

et al. 2024

Healthcare

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The measurement of musculoskeletal tissue properties and loading patterns during physical activity is important for understanding the adaptation mechanisms of tissues such as bone, tendon, and muscle tissues, particularly with injury and repair. Although the properties and loading of these connective tissues have been quantified using direct measurement techniques, these methods are highly invasive and often prevent or interfere with normal activity patterns. Indirect biomechanical methods, such as estimates based on electromyography, ultrasound, and inverse dynamics, are used more widely but are known to yield different parameter values than direct measurements. Through a series of literature searches of electronic databases, including Pubmed, Embase, Web of Science, and IEEE Explore, this paper reviews current methods used for the in vivo measurement of human musculoskeletal tissue and describes the operating principals, application, and emerging research findings gained from the use of quantitative transmission-mode ultrasound measurement techniques to non-invasively characterize human bone, tendon, and muscle properties at rest and during activities of daily living. In contrast to standard ultrasound imaging approaches, these techniques assess the interaction between ultrasound compression waves and connective tissues to provide quantifiable parameters associated with the structure, instantaneous elastic modulus, and density of tissues. By taking advantage of the physical relationship between the axial velocity of ultrasound compression waves and the instantaneous modulus of the propagation material, these techniques can also be used to estimate the in vivo loading environment of relatively superficial soft connective tissues during sports and activities of daily living. This paper highlights key findings from clinical studies in which quantitative transmission-mode ultrasound has been used to measure the properties and loading of bone, tendon, and muscle tissue during common physical activities in healthy and pathological populations.

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“…Musculoskeletal modeling can quantify articular contact forces within the tibiofemoral joint as well as muscle activation strategies by using inverse dynamics calculations and muscle optimization methods [ 17 ]. These have been validated for tibiofemoral contact forces using instrumented knee prostheses [ 25 ], hip contact forces [ 1 ], and for muscle activation using electromyography [ 16 , 44 ]. Therefore, it is appropriate to use musculoskeletal modeling to assess compartmental loading of the tibiofemoral joint in stair ambulation.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Asymmetry in Knee and Hip Musculoskeletal Loading During Stair Ascending/Descending in Individuals with Unilateral Mild-to-Moderate Medial Knee Osteoarthritis

Liu¹,

Amiri²,

McGregor³

et al. 2023

Ann Biomed Eng

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Most cases of unilateral knee osteoarthritis (OA) progress to bilateral OA within 10 years. Biomechanical asymmetries have been implicated in contralateral OA development; however, gait analysis alone does not consistently detect asymmetries in OA patient gait. Stair ambulation is a more demanding activity that may be more suited to reveal between-leg asymmetries in OA patients. The objective of this study was to investigate the between-leg biomechanical differences in patients with unilateral mild-to-moderate knee OA. Sixteen unilateral mild-to-moderate medial knee OA patients and 16 healthy individuals underwent kinematic and kinetic analysis of stair ascent and descent. Stair ascent produced higher loading and muscle forces in the unaffected limb compared to the OA limb, and stair descent produced lower loading on the OA limb compared to healthy subjects. These biomechanical differences were apparent in the ankle, knee, and hip joints. The implications of these findings are that OA patients rely more heavily on their unaffected sides than the affected side in stair ascent, a strategy that may be detrimental to the unaffected joint health. The reduction in affected limb loading in stair descent is thought to be related to minimizing pain.

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Prediction of in vivo hip contact forces during common activities of daily living using a segment-based musculoskeletal model

Cited by 7 publications

References 56 publications

Characterization of muscle recruitment during gait of bilateral transfemoral and through-knee persons with limb loss

Characterization of muscle recruitment during gait of bilateral transfemoral and through-knee persons with limb loss

The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques

Bilateral Asymmetry in Knee and Hip Musculoskeletal Loading During Stair Ascending/Descending in Individuals with Unilateral Mild-to-Moderate Medial Knee Osteoarthritis

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