Prediction of individual response to controlled ovarian hyperstimulation by means of a clomiphene citrate challenge test

Loumaye, Ernest; Billion, J M; Mine, Jean-Michel; Psalti, I.; Pensis, Manuel; Thomas, Karl

doi:10.1016/s0015-0282(16)53284-1

Cited by 151 publications

(53 citation statements)

References 17 publications

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“…increased to 40.6% when CCCT was performed which indicated that a significant number of patients with restricted ovarian reserve would have been missed if the challenge test was not applied. Our data are in concordance with earlier studies reporting CCCT as being more sensitive than day 3 FSH alone in predicting both cycle cancellation and pregnancy rates (2,28,29). In one study, approximately twice as many patients were identified by using CCCT as compared to basal FSH screening alone and the cancellation rate was found to be higher in women with abnormal test results (29).…”

Section: Discussionsupporting

confidence: 92%

“…In one study, approximately twice as many patients were identified by using CCCT as compared to basal FSH screening alone and the cancellation rate was found to be higher in women with abnormal test results (29). Loumaye et al evaluated CCCT by defining a threshold value of 26 IU/L as the sum of cycle day 3 and 10 FSH values and concluded that predictive value of an abnormal test for failing to conceive was 100% (28). Recently, it was reported that an abnormal CCCT had a positive predictive value of 93% for pregnancy and a negative predictive value of 80% for cycle cancellation (30).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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Purpose : To compare basal and clomiphene citrate (CC) induced follicle-stimulating hormone (FSH), estradiol (E 2 ), and inhibin B levels with ultrasound indices of ovarian reserve in infertile women and to test the prognostic value of these tests on response to ovarian stimulation in in vitro fertilization (IVF). Methods : Fifty-six patients had basal and CC induced serum hormone levels and ultrasound measured mean ovarian volume (MOV) and mean antral follicle counts (MFC). Thirty-two patients were then appropriately selected to have a total of 41 cycles of IVF/ICSI treatment. Results : Women with diminished ovarian reserve had lower MOV, MFC, day 3 and day 10 inhibin B levels ( p < 0.001). Only basal and CC induced FSH and inhibin B correlated with MOV and MFC. Poor responders in IVF/ICSI had higher basal FSH ( p < 0.05), lower basal and induced inhibin B levels ( p < 0.05), and lower MOV and MFC ( p < 0.01) than normal responders. Ovarian volume alone was better than age and basal hormones in predicting poor ovarian response, while abnormal CC test was the only independent significant factor in predicting ovarian response. However, age was the only independent predictor of pregnancy in IVF as compared to hormonal and ultrasound indices of ovarian reserve. Conclusion : CC test and ovarian volume are better than other hormonal and sonographic tests in predicting the response to ovarian stimulation in IVF cycles.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Erdem

Gursoy

et al. 2004

J Assist Reprod Genet

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“…Although a highly sensitive and specific diagnostic test for diminished ovarian reserve (DOR) does not exist, an elevated basal FSH or an abnormal response to provocative testing, such as a clomiphene citrate challenge test, have been used to define this poor prognosis group (20,21,23,24). In addition to decreased ovarian responsiveness with gonadotropin stimulation and subsequent lower pregnancy rates, these women also have an increased rate of pregnancy wastage, irrespective of age, further contributing to low delivery rates (25).…”

Section: Discussionmentioning

confidence: 99%

The combined effect of age and basal follicle-stimulating hormone on the cost of a live birth at assisted reproductive technology

Henne

Stegmann

Neithardt

et al. 2008

Fertility and Sterility

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Objective-To predict the cost of a delivery following assisted reproductive technologies (ART).Design-Cost analysis based on retrospective chart analysis. Setting-University-based ART programPatients-Women aged ≥26 and ≤42 years with FSH levels ≤ 12 IU/L on day 3 undergoing a first cycle of fresh, non-donor ART.Interventions-Logit regression using a fractional polynomial model of age and basal FSH was used to estimate the probability of a live birth. Cost analysis was applied to the resulting prediction.Main outcome measure(s)-The predicted probability of live-birth following ART based on a woman's age and FSH and the associated cost of a live birth.Result(s)-Analysis of 1,238 first ART cycles produced a prediction model for live-birth rates following ART incorporating both age and FSH. A cost analysis based upon combination of age and FSH revealed the cost of a live birth exceeded $100,000 when the probability of a live birth fell below 15% and the cost rose exponentially at lower probabilities of live birth.Conclusions(s)-Based upon a woman's age and FSH and expected cost for a live birth using ART may be calculated. At live birth rates below 5%, the cost of ART is high and greatly exceeds the cost of donor cycles. This information is vital for patient counseling.

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“…Depletion in the quantity of ovarian follicles and concurrent reduction in oocyte quality have been termed as diminished ovarian reserve and are thought to be the main reasons for declining maternal reproductive performance with age (1,2). Various dynamic and static tests have been proposed to predict ovarian function and reserve, such as basal serum Follicle stimulating hormone (b-FSH) levels, the sonographic assessment of the ovarian antral follicle count and ovarian volume, the clomiphene citrate challenge test, the antimullerian hormone levels, the exogenous FSH stimulation test, the gonadotropin releasing hormone (GnRH) agonist stimulation test, and basal serum inhibin B levels among others (3)(4)(5)(6)(7)(8)(9). A commonly utilized test is the measurement of b-FSH levels in the early follicular phase (cycle days 2-5) (10).…”

Section: Introductionmentioning

confidence: 99%

Predicting pregnancy in women undergoing in-vitro fertilization with basal serum follicle stimulating hormone levels between 10.0 and 11.9 IU/L

Levin¹,

Jun²,

Dahan³

2015

J Turkish German Gynecol Assoc

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Prediction of individual response to controlled ovarian hyperstimulation by means of a clomiphene citrate challenge test

Cited by 151 publications

References 17 publications

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor Ovarian Response in IVF

The combined effect of age and basal follicle-stimulating hormone on the cost of a live birth at assisted reproductive technology

Predicting pregnancy in women undergoing in-vitro fertilization with basal serum follicle stimulating hormone levels between 10.0 and 11.9 IU/L

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