Prediction of large‐for‐gestational‐age infant by fetal growth charts and hemoglobin A1c level in pregnancy complicated by pregestational diabetes

Abstract

Objectives To compare the ability of three fetal growth charts (Fetal Medicine Foundation (FMF), Hadlock and National Institutes of Child Health and Human Development (NICHD) race/ethnicity‐specific) to predict large‐for‐gestational age (LGA) at birth in pregnant individuals with pregestational diabetes, and to determine whether inclusion of hemoglobin A1c (HbA1c) level improves the predictive performance of the growth charts. Methods This was a retrospective analysis of individuals with Type‐1 or Type‐2 diabetes with a singleton pregnancy that resulted in a non‐anomalous live birth. Fetal biometry was performed between 28 + 0 and 36 + 6 weeks of gestation. The primary exposure was suspected LGA, defined as estimated fetal weight ≥ 90th percentile using the Hadlock (Formula C), FMF and NICHD growth charts. The primary outcome was LGA at birth, defined as birth weight ≥ 90th percentile, using 2017 USA natality reference data. The performance of the three growth charts to predict LGA at birth, alone and in combination with HbA1c as a continuous measure, was assessed using the area under the receiver‐operating‐characteristics curve (AUC), sensitivity, specificity, positive predictive value and negative predictive value. Results Of 358 assessed pregnant individuals with pregestational diabetes (34% with Type 1 and 66% with Type 2), 147 (41%) had a LGA infant at birth. Suspected LGA was identified in 123 (34.4%) by the Hadlock, 152 (42.5%) by the FMF and 152 (42.5%) by the NICHD growth chart. The FMF growth chart had the highest sensitivity (77% vs 69% (NICHD) vs 63% (Hadlock)) and the Hadlock growth chart had the highest specificity (86% vs 76% (NICHD) and 82% (FMF)) for predicting LGA at birth. The FMF growth chart had a significantly higher AUC (0.79 (95% CI, 0.74–0.84)) for LGA at birth compared with the NICHD (AUC, 0.72 (95% CI, 0.68–0.77); P < 0.001) and Hadlock (AUC, 0.75 (95% CI, 0.70–0.79); P < 0.01) growth charts. Prediction of LGA improved for all three growth charts with the inclusion of HbA1c measurement in comparison to each growth chart alone (P < 0.001 for all); the FMF growth chart remained more predictive of LGA at birth (AUC, 0.85 (95% CI, 0.81–0.90)) compared with the NICHD (AUC, 0.79 (95% CI, 0.73–0.84)) and Hadlock (AUC, 0.81 (95% CI, 0.76–0.86)) growth charts. Conclusions The FMF fetal growth chart had the best predictive performance for LGA at birth in comparison with the Hadlock and NICHD race/ethnicity‐specific growth charts in pregnant individuals with pregestational diabetes. Inclusion of HbA1c improved further the prediction of LGA for all three charts. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Prediction of large‐for‐gestational age at 36 weeks' gestation: two‐dimensional ultrasoundvsthree‐dimensional ultrasoundvsmagnetic resonance imaging

“…Many ways of calculating EFW have been described, with a debate still ongoing about the most accurate method of weight projection [10][11][12][13][14][15][16][17] . To date, twodimensional ultrasound (2D-US) with the Hadlock formula 17 is considered the most accurate method of predicting birth weight (BW) 18 , despite identifying only 73% of LGA neonates with BW ≥ 95 th percentile at a fixed false-positive rate of 10% 19 .…”