Prediction of live birth in frozen-thawed single blastocyst transfer cycles by pre-freeze and post-thaw morphology

Abstract

not applicable.

Euploidy Predictability of Human Blastocyst Inner Cell Mass and Trophectoderm Grading

“…This study clearly shows in our program that good to high quality blastocysts have an increased potential for euploidy, while fair and poor quality blastocysts are more likely aneuploid. Interestingly, this study provides data to support the concept that a high quality TE is the best predictor for selecting a single blastocyst for ET to optimize pregnancy outcomes [7].…”

“…With two independent blastocyst grades, it has been debated whether preference should be given to the ICM or TE. Ahlstrom and coworkers [7] recently provided strong embryo transfer evidence that an "A" quality TE grade versus ICM grade is more predictive of live birth success based on more than a thousand frozen-thawed, non-PGS transfer cycles. When euploidy status is not determined, morphology and morphokinetics are the leading options available for embryo selection [3].…”

The optimal timing of blastocyst vitrification after trophectoderm biopsy of preimplantation genetic screening

“…The re-expansion grade after warming has been used to indicate blastocyst survivability and quality after vitrification [21][22][23][24][25][26] and the clinical pregnancy rate of rapidly re-expanding blastocysts (within 2-4 h) was more than double the rate of slowly re-expanding blastocysts [21]. In this study, blastocyst degeneration was not observed after TE biopsy and only euploid blastocysts were selected for embryo transfer.…”

Vitrification, an efficient cryopreservation procedure but still rising some debates

“…By contrast, neither inner cell mass nor blastocyst expansion was statistically significantly related (17,18). In a more recent article, Ahlström et al (19) analyse which prefreeze morphological parameters can be used to predict live birth outcomes after vitrified/warmed blastocyst transfer cycles. They stated that blastocoele expansion and trophectoderm grade were identified as the most significant pre-freeze morphological predictors of live birth.…”