Prediction of marrow toxicity in patients treated by intravenous infusion of 5 fluorouracil

Hillcoat, B L; Banerjee, Madhumita; McCulloch, P B; Williams, Cheyenne

doi:10.1016/0014-2964(77)90233-x

Cited by 4 publications

(1 citation statement)

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“…The concentration of interferon used in our study coincides with these levels. These additional data, we believe, make it likely that our in vitro observation on the effect of human interferons on human granulocytic progenitor cells may have clinical relevance, in the same way as this assay technique predicted bone mar row toxicity in cancer patients managed with infusions of 5-fluorouracil [8],…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Human Leukocyte and Fibroblast Interferons on Normal and Chronic Myelogenous Leukemic Granulocytic Progenitor Cells

et al. 1981

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Inhibitory effects of two human interferon preparations, leukocyte interferon (Le-IF) and fibroblast interferon (F-IF), on granulocytic progenitor cells (CFU-C) from hematologically normal cancer patients and from patients with chronic myelogenous leukemia were evaluated. There was a wide variation in sensitivity of CFU-C to both Le-IF and F-IF. F-IF was more inhibitory against CFU-C than Le-IF. Normal CFU-C and chronic myelogenous Leukemia CFU-C were equally inhibited by both interferons. Effects of both interferons were neutralized by corresponding specific antisera but not by the other antisera. These observations confirmed that differences in immunogenicity of the interferons may attend their different origins.

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Section: Discussionmentioning

confidence: 99%