Prediction of Memory Rehabilitation Outcomes in Traumatic Brain Injury by Using Functional Magnetic Resonance Imaging

Strangman, Gary E.; OʼNeil-Pirozzi, Therese M.; Goldstein, Richard; Kelkar, Kalika; Katz, Douglas I.; Burke, David T.; Rauch, Scott L.; Savage, Cary R.; Glenn, Mel B.

doi:10.1016/j.apmr.2008.02.011

Cited by 52 publications

(53 citation statements)

References 65 publications

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“…These findings are in line with the literature showing participation of frontal and temporal areas in processes such as encoding, storage, and retrieval of information, in addition to, strategy and information processing speed 13 . One limitation of the study is the relatively small number of samples, which did not allow for a robust statistical analysis.…”

supporting

confidence: 82%

“…Impairments of executive functions affect mental flexibility, planning, self-monitoring, and problem solving 2 . These impairments can compromise other abilities, such as attention and memory 13,14 . After the period of post-traumatic amnesia (PTA), patients who experienced severe TBI may present memory disorders of variable intensity 15 ; damages of short term and long term 7,[9][10][11]16,17 memory.…”

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confidence: 99%

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Cognitive deficits in patients with mild to moderate traumatic brain injury

Miotto

Cinalli

Serrão

et al. 2010

Arq. Neuro-Psiquiatr.

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Traumatic brain injury (TBI) is one of the most frequent causes of brain damage. Cognitive deficits reported in the literature after moderate to severe TBI include memory, language, executive functions, attention and information processing speed impairments. However, systematic studies on patients with mild TBI are scarce although neuropsychological changes are present. Objective: To investigate the cognitive functioning of patients with mild to moderate TBI. Method: We evaluated 12 patients with mild to moderate TBI using a comprehensive protocol (PN01) of neuropsychological tests. Results: There were significant deficits of episodic memory including immediate and delayed verbal memory recall, verbal recognition, immediate and delayed visual memory recall, naming, verbal fluency and information processing speed. Conclusion: These results emphasize the importance of comprehensive neuropsychological assessments even in cases of mild TBI in order to identify impaired and preserved functions providing adequate managing including rehabilitation programs for each case. Key words: traumatic brain injury, cognitive deficits, mild to moderate level.Alterações neuropsicológicas em pacientes com traumatismo crânio encefálico levemoderado RESUMO Traumatismo craniencefálico (TCE) é uma das causas mais freqüentes de lesão cerebral. São relatados na literatura déficits cognitivos após TCE moderado-grave relacionados à memória, linguagem, funções executivas, atenção e velocidade de processamento de informações. Estudos em pacientes com TCE leve são escassos embora alterações neuropsicológicas sejam encontradas nestes pacientes. Objetivo: Investigar o funcionamento cognitivo de pacientes com TCE leve e moderado através de um protocolo abrangente (PN01) de testes neuropsicológicos. Método: Foram avaliados 12 pacientes com TCE leve e moderado. Resultados: Foram identificados déficits graves de memória episódica verbal para evocação imediata, tardia e de reconhecimento, de memória episódica visuo-espacial para evocação imediata e tardia, nomeação, fluência verbal nominal e velocidade de processamento de informações. Conclusão: Os resultados do estudo argumentam a favor da importância de avaliação neuropsicológica abrangente mesmo em casos de TCE leve a fim de se identificar funções comprometidas e preservadas, proporcionando condutas e programas de reabilitação adequados a cada caso. Palavras-chave: traumatismo crânio encefálico, déficits cognitivos, grau leve e moderado.

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supporting

confidence: 82%

mentioning

confidence: 99%

Cognitive deficits in patients with mild to moderate traumatic brain injury

Miotto

Cinalli

Serrão

et al. 2010

Arq. Neuro-Psiquiatr.

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“…fMRI has been used to examine functional activation patterns in patients with TBI at all levels of severity in both adults (Cazalis et al, 2006;Christodoulou et al, 2001;Maruishi et al, 2007;McAllister et al, 1999McAllister et al, , 2001Newsome et al, 2007b;Perlstein et al, 2004;Rasmussen et al, 2008;Scheibel et al, 2003Scheibel et al, , 2007Schmitz et al, 2006;Soeda et al, 2005) and children (Lovell et al, 2007;Newsome et al, 2007a;Scheibel et al, 2003). fMRI may also be important in understanding recovery from mild TBI (Chen et al, 2004(Chen et al, , 2007(Chen et al, , 2008Jantzen et al, 2004;Lovell et al, 2007) or in rehabilitation efforts in more severe forms of TBI (Kim, Y. H. et al, 2009;Laatsch, L et al, 2004a,b;Strangman et al, 2005Strangman et al, , 2008. More recently, there has been increasing interest in the concept of what the brain does at rest, and data have been collected with a subject in the scanner, using the BOLD techniques but without any stimulus.…”

Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

116

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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“…Several examples of task-related fMRI studies in TBI have documented either abnormalities in brain activity in patients with normal structural MRI or changes that were not predictable based on findings apparent on structural MRI (59). Tasks for TBI subjects have included those requiring working memory (99)(100)(101)(102)(103), verb generation (104), reading comprehension (103), short-term verbal learning and memory (105,106), self-initiated movements (107,108), and self-appraisal (109). However, the precise definition of task administration and performance assessment presents significant additional barriers to standardization of these task-related fMRI studies.…”

Section: Conventional Mri Techniquesmentioning

confidence: 99%

Common data elements in radiologic imaging of traumatic brain injury

Haacke,

Duhaime,

Gean

et al. 2010

Magnetic Resonance Imaging

166

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Traumatic brain injury (TBI) has a poorly understood pathology. Patients suffer from a variety of physical and cognitive effects that worsen as the type of trauma worsens. Some noninvasive insights into the pathophysiology of TBI are possible using magnetic resonance imaging (MRI), computed tomography (CT), and many other forms of imaging as well. A recent workshop was convened to evaluate the common data elements (CDEs) that cut across the imaging field and given the charge to review the contributions of the various imaging modalities to TBI and to prepare an overview of the various clinical manifestations of TBI and their interpretation. Technical details regarding state-of-the-art protocols for both MRI and CT are also presented with the hope of guiding current and future research efforts as to what is possible in the field. Stress was also placed on the potential to create a database of CDEs as a means to best record information from a given patient from the reading of the images.

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Prediction of Memory Rehabilitation Outcomes in Traumatic Brain Injury by Using Functional Magnetic Resonance Imaging

Cited by 52 publications

References 65 publications

Cognitive deficits in patients with mild to moderate traumatic brain injury

Cognitive deficits in patients with mild to moderate traumatic brain injury

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Common data elements in radiologic imaging of traumatic brain injury

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