Prediction of metastatic status in non-seminomatous testicular cancer

Ruf, Christian; Sachs, Sharona; Khalili-Harbi, N.; Isbarn, Hendrik; Wagner, Walter; Matthies, Cord; Meineke, V.; Fisch, Margit; Chun, Felix K.-H.; Abend, Michael

doi:10.1007/s00345-013-1194-0

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…A potential abdominal malignancy may have been a factor causing the significant positivity of hCG. LDH, β-hCG and AFP serum markers are generally effective tools for the evaluation of risk stratifications and treatment decisions, however, combination analysis and general evaluation may additionally be necessary (16,18).…”

Section: Discussionmentioning

confidence: 99%

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

et al. 2015

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Abstract. Pure yolk sac tumors are extremely rare in adults; to the best of our knowledge, <20 cases have been reported. Multiple metastases originating from a pure yolk sac testicular tumor, descending from an intra-abdominal testis, are additionally extremely rare. In the present case, a man exhibiting a 30-year history of cryptorchidism and indirect inguinal hernia, was admitted to the Department of Urology (The Second Xiangya Hospital, Changsha, China) due to a mass that had descended from the abdominal cavity 7 months previously. Elevated levels of specific serum marker (α-fetoprotein, lactate dehydrogenase and human chorionic gonadotropin ) did not indicate potential testicular germ cell types prior to surgery and pathological examination. Pathological results and immunohistochemistry revealed a testicular pure yolk sac tumor subsequent to surgery. The present case report and literature review describes the typical characteristics of an adult testicular yolk sac tumor, as well as the diagnosis and management of the disease.

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Section: Discussionmentioning

confidence: 99%

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

et al. 2015

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“…There is no definite knowledge for rete testis invasion as opposed to seminomas for NS tumors. Ruf et al [19] found a close relationship with infiltration of the rete testis and metastatic status in nonseminomatous germ cell tumors. But there is no clear consensus on this issue in the current guidelines.…”

Section: Discussionmentioning

confidence: 99%

What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Ediz¹,

İhvan²

2019

Urol Int

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Background: The significance of hilar soft tissue invasion of rete testis in malign germ cell tumors is still controversial on current guidelines. Objectives: We aimed to investigate the importance of hilar soft tissue involvement in germ cell tumors and evaluated the possibility of a risk factor such as rete testis. Method: Totally, 59 radical orchiectomy specimens operated between 2007 and 2015 at our clinics. All records were retrospectively researched. Patients’ age, level of tumor markers, tumor size, histological subtype, clinical stage, presence or absence of carcinoma in situ, vascular/lymphatic and/or hilar soft tissue invasion, tumoral necrosis, number, site and diameter of metastasis, type of further treatment (radiotherapy or chemotheraphy) and follow-up period were recorded and evaluated for all patients. Results: Twenty-six of totally 59 malign germ cell tumors were seminomatous and 33 were nonseminomatous (NS). Mean patients age was 38.54 years (range 17–89 years). Mean follow-up duration was 39.84 months (range 3–96). Serum tumor marker levels were found associated with rete testis invasion (p = 0.035). Hilar soft tissue invasion was significantly associated with vascular invasion (p = 0.001). As it was expected, vascular invasion was significantly associated with metastasis (p = 0.024). Conclusions: We concluded that there is a strong association between hilar soft tissue invasion and vascular invasion. Especially in NS germ cell tumors, hilar soft tissue involvement a risk factor for prognosis and to determine the need for additional treatment. According to our study, hilar soft tissue status should be reported on routine pathology report.

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“…The approach is similar to the panel of biomarkers for testicular cancer diagnosis and treatment guidance. In testicular cancer, for example, the use of LDH, BHCG, and AFP (lactate dehydrogenase, beta human chorionic gonadotropin, alpha fetoprotein) allow for suspicion of specific tumor type and tumor burden [19]. We Highly expressed in cancer cells.…”

Section: Application Of Pca Biomarkers In the Clinicmentioning

confidence: 99%

Prostate Cancer Biomarkers– A Bench to Bedside Perspective

Abouelleil

Bratslavsky²,

Bourboulia³

2014

Cancer Sci Res

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Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and is responsible for the second most common age-adjusted death rate due to cancer among men in the US, after lung cancer [1]. The prevalence of PCa increases with age with the chance of detecting PCa in an 80 year-old male being as high as 60% [2]. While PCa is generally considered a disease of "old age" with most men dying with and not from PCa, the mortality from PCa is still high, with estimated one PCa death globally every four minutes [3]. Clinically, there is an arsenal of tools for managing or treating PCa, including surgical removal of the prostate, radiation, hormone deprivation, ablative therapies, or active surveillance. Unfortunately, side effects and complications from treatment are not benign and depending on the treatment modality may include urinary incontinence, erectile dysfunction, hemorrhagic cystitis and lower urinary tract symptoms (LUTS). Currently, Prostate-Specific Antigen (PSA) screening and Digital Rectal Exams (DRE) are most commonly used and widely available means of screening, and recommended by the American Urological Association (AUA) [4].

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Prediction of metastatic status in non-seminomatous testicular cancer

Abstract: No single parameter was able to discriminate metastatic from non-metastatic NSGCT, but combinations of parameters in two predictive models accurately identified the metastatic status in 23 % of the cases in our sample.

Cited by 6 publications

References 27 publications

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature

What Is the Significance of Rete Testis Invasion by Malign Germ Cell Tumor and Does Hilum Predict Metastasis?

Prostate Cancer Biomarkers– A Bench to Bedside Perspective

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