Prediction of Neurocognitive Outcome in Adult Brain Tumor Patients

Kaleita, Thomas A.; Wellisch, David K.; Cloughesy, Timothy F.; Ford, Judith M.; Freeman, Donald T.; Belin, Thomas R.; Goldman, Jeffrey

doi:10.1023/b:neon.0000021900.29176.58

Cited by 42 publications

(50 citation statements)

References 25 publications

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“…Age was one of the strongest determinants of cognitive outcome in a series of 79 primary brain tumour patients assessed at UCLA (Kaleita et al . ). In this study, authors showed that the strongest predictor of performance on neurocognitive test was age.…”

Section: Methodsmentioning

confidence: 97%

Neurocognitive functions and health-related quality of life in glioblastoma patients: a concise review of the literature

Bergo

Lombardi²,

Guglieri

et al. 2015

Eur J Cancer Care

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The maintenance of quality of life in patients with high-grade glioma is an important endpoint during treatment, particularly in those with glioblastoma multiforme, given its dismal prognosis; thus, the primary aims of treatments are to reduce morbidity, restore or preserve neurological functions, and the capacity to perform daily activities. This review aims to summarise what is currently known about neurocognitive outcome and quality of life in patients with high-grade glioma, particularly in glioblastoma patients. We considered all the variables that can influence neurocognitive functions, the perception of quality of life and their role as predictors for treatment outcomes.

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Section: Methodsmentioning

confidence: 97%

Neurocognitive functions and health-related quality of life in glioblastoma patients: a concise review of the literature

Bergo

Lombardi²,

Guglieri

et al. 2015

Eur J Cancer Care

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“…We utilized a multiple cutoff approach such that better‐performing survivors needed to score no more than 1.5 SD below the mean on all selected measures to minimize the likelihood that group membership was attained by chance alone on a single measure. Lastly, our sample size was somewhat larger than other studies examining cognitive functioning in brain tumor survivors …”

Section: Discussionmentioning

confidence: 98%

“…Lastly, our sample size was somewhat larger than other studies examining cognitive functioning in brain tumor survivors. 11,12,28,[37][38][39]…”

Section: Study Limitationsmentioning

confidence: 99%

Cognitive functioning following brain irradiation as part of cancer treatment: Characterizing better cognitive performance

et al. 2019

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Objective Although brain radiation therapy (RT) impacts cognitive function, little is known about the subset of survivors with minimal cognitive deficits. This study compares the characteristics of patients receiving brain irradiation as part of cancer treatment with minimal cognitive deficits to those with poorer cognitive functioning. Methods Adults at least 6 months postbrain RT (N = 198) completed cognitive measures of attention, memory, and executive functions. Cognitive functioning was categorized into better‐ and poorer‐performing groups, with better‐performing survivors scoring no worse than 1.5 standard deviations below the published normative mean on all cognitive measures. Logistic regression was used to identify variables associated with better‐performing group membership. Results Approximately 25% of the sample met the criteria for the better‐performing group. In unadjusted analyses, RT type (whole brain irradiation and partial brain irradiation), sedating medications, and fatigue were independently associated with cognition. Sociodemographic and other clinical characteristics were not significant. In adjusted analyses, only fatigue remained significantly associated with group membership (OR = 1.05, 95% CI = 1.01‐1.09, P = .009). Conclusions There is a subgroup of survivors with minimal long‐term cognitive deficits despite undergoing a full course of brain RT as part of cancer treatment. Lower fatigue had the strongest association with better cognitive performance. Interventions targeting cancer‐related fatigue may help buffer the neurotoxic effects of brain RT.

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“…(3) Has there been cognitive decline secondary to tumor recurrence (Bosma et al 2007;Glosser et al 1997)? (4) Does the rehabilitation program or any of its components improve (or affect) cognitive functioning (Kaleita et al 2004;Langer et al 2002;Mabbott et al 2008;Mehta et al 2003;Meyers et al 2004)? (5) Can survival rates be predicted using estimates of baseline cognitive functioning (Armstrong et al 2003;Meyers et al 2000)?…”

Section: Multiple Concussionsmentioning

confidence: 99%

The Little Black Book of Neuropsychology

Schoenberg¹,

Scott²

2011

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Prediction of Neurocognitive Outcome in Adult Brain Tumor Patients

Cited by 42 publications

References 25 publications

Neurocognitive functions and health-related quality of life in glioblastoma patients: a concise review of the literature

Neurocognitive functions and health-related quality of life in glioblastoma patients: a concise review of the literature

Cognitive functioning following brain irradiation as part of cancer treatment: Characterizing better cognitive performance

The Little Black Book of Neuropsychology

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