Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Gallmeier, Kerstin; Becker, Erika; Kirsten, Anne; Wölke, Gabriele; Manuwald, O; Meyer, Heike; Magnussen, H; Nowak, Dennis; Heinrich, Joachim

doi:10.1183/09031936.00012813

Cited by 10 publications

(18 citation statements)

References 30 publications

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“…A similar study in German adults aged 25‐74 years also showed that allergic sensitization to outdoor allergens was a predictor for the development of allergic rhinitis during a 10‐year period . Furthermore, in a German study, a cohort of 21‐47 years olds was followed up after 20 years, and here, new nasal allergy was predicted by eczema, any positive SPT or specific IgE . A positive reaction to birch pollen was the strongest predictor for new‐onset nasal allergy.…”

Section: Discussionsupporting

confidence: 54%

“…Comparing results from different studies can be challenging due to different definitions, diagnostic criteria and study designs and measurements of sensitization are not always included. Several prospective, population‐based cohort studies have evaluated time trends of allergic sensitization and atopic diseases during childhood and a few have been performed during adulthood . However, studies prospectively evaluating the course of allergic sensitization and atopic diseases from childhood or adolescence to adulthood are rare.…”

Section: Introductionmentioning

confidence: 99%

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Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis

Mørtz

Andersen

Poulsen

et al. 2018

Allergy

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Background: While much is known on childhood atopic diseases, knowledge about persistence of atopic diseases from childhood to adulthood is limited. We therefore aimed to study the clinical course of atopic diseases and type I sensitization prospectively in an unselected cohort of adolescents followed into adulthood.Methods: A cohort of unselected 8th-grade school children (mean age 14 years) established in 1995 and followed up in 2010 were evaluated with questionnaire, clinical examination, skin prick tests and measurements of specific IgE. Results:The lifetime prevalence of atopic diseases was high and increased significantly from adolescence (31%) to adulthood (57%); particularly allergic rhinitis increased with an incidence rate of 17.5/1000 person-years. Childhood predictors for adult allergic rhinitis were atopic dermatitis, asthma and asymptomatic sensitization to pollen and house dust mite. Among those with asymptomatic sensitization in adolescence, 53%-78% developed allergic rhinitis in adulthood. Furthermore, type I sensitization increased significantly from adolescence to adulthood mostly due to increased sensitization to pollen. Type I sensitization was found mainly in those with allergic rhinitis. A high number of adults had oral allergy symptoms due to the high number of birch pollen allergic individuals.Conclusion: Persistence of atopic diseases in adulthood is common, and a high proportion of the adult population is sensitized giving a high prevalence of allergic rhinitis. Many with asymptomatic sensitization in adolescence will develop allergic rhinitis in adult life. The focus should be on prevention of atopic diseases and sensitization already in childhood. K E Y W O R D S allergic rhinitis, asthma, atopic dermatitis, cohort study, sensitization 1 | INTRODUCTION Atopic diseases are among the most common chronic diseases in children and adolescents, and an increasing prevalence has been observed over several decades. 1,2 Due to the cohort effect, this increase should now appear in adulthood. An increase in allergic rhinitis and asthma among young adults has been shown in different cross-sectional studies over time. 3-5 A few studies have also reported an increased prevalence of sensitization over time when comparing different cohorts. 3,6-8 A recent cross-sectional study in

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis

Mørtz

Andersen

Poulsen

et al. 2018

Allergy

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“…Allergic rhino-conjunctivitis is a well-known risk factor for asthma [ 4 , 17 , 19 , 21 ] and is a reasonable proxy for allergic sensitisation, at least among younger and middle-aged adults [ 21 ]. In the current study it was the strongest and most stable risk factor for asthma, which further strengthens the causality of the association.…”

Section: Discussionmentioning

confidence: 99%

High but stable incidence of adult-onset asthma in northern Sweden over the last decades

et al. 2021

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BackgroundThe prevalence of asthma has increased both among children and adults during the latter half of the 20th century. The prevalence among adults is affected by the incidence of asthma in childhood but also in adulthood. Time trends in asthma incidence are poorly studied.AimThe aim was to study the incidence of adult-onset asthma from 1996–2006 and 2006–2016, and compare the risk factor patterns.MethodsWithin the Obstructive Lung Disease in Northern Sweden (OLIN) studies, two randomly selected population-based samples in ages 20–69 years participated in postal questionnaire surveys about asthma in 1996 (n=7104, 85%) and 2006 (n=6165, 77%), respectively. A 10-year follow-up of the two cohorts with the same validated questionnaire was performed, and n=5709 and n=4552, respectively, responded. Different definitions of population at risk were used in the calculations of asthma incidence. The protocol followed a study performed 1986 to 1996 in the same area.ResultsThe crude incidence rate of physician-diagnosed asthma was 4.4/1000/year (men 3.8, women 5.5) from 1996–2006, and 4.8/1000/year (men 3.7, women 6.2) from 2006–2016. When correcting for possible under-diagnosis at study entry, the incidence rate was 2.4/1000/year from 1996–2006 and 2.6/1000/year from 2006–2016. The incidence rates were similar across age groups. Allergic rhino-conjunctivitis was the main risk factor for incident asthma in both observation periods (risk ratios 2.4–2.6).ConclusionsThe incidence of adult-onset asthma has been stable over the last two decades, and on similar level since the 1980s. The high incidence contributes to the increase in asthma prevalence.

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“…The sensitivity and specificity of each diagnostic test were obtained from five different published articles [7][8][9][10][11] (Table 1). Karrasch et al 7 assessed FeNO accuracy for making the diagnosis of asthma by conducting a systematic review and diagnostic meta-analysis of 26 different studies, which account for a total of 4518 participants.…”

Section: Data Sourcesmentioning

confidence: 99%

“…11 evaluated the diagnostic utility of skin prick tests (SPTs) and radioallergosorbent tests (RASTs) in 1185 patients during 20 years.…”

mentioning

confidence: 99%

Economic Evaluation of the Use of FeNO for the Diagnosis and Management of Asthma Patients in Primary Care in Sweden

Darbà¹,

Ascanio²,

Syk³

et al. 2021

CEOR

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Prediction of new-onset asthma and nasal allergy by skin prick test and RAST in a cohort of adults

Cited by 10 publications

References 30 publications

Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis

Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis

High but stable incidence of adult-onset asthma in northern Sweden over the last decades

Economic Evaluation of the Use of FeNO for the Diagnosis and Management of Asthma Patients in Primary Care in Sweden

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