Prediction of new onset atrial fibrillation in patients with acute coronary syndrome undergoing percutaneous coronary intervention using the C2HEST and mC2HEST scores: A report from the multicenter REALE-ACS registry

Biccirè, Flavio Giuseppe; Tanzilli, Gaetano; Prati, Francesco; Sammartini, Emanuele; Gelfusa, Martina; Celeski, Mihail; Budassi, Simone; Barillà, Francesco; Lip, Gregory Y.H.; Pastori, Daniele

doi:10.1016/j.ijcard.2023.05.023

Cited by 9 publications

(1 citation statement)

References 25 publications

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“…Furthermore, in a selected cohort of 189 patients undergoing catheter ablation, the C 2 HEST score showed a good predictive value to predict recurrences of AF (area under curve [AUC] 0.769) [14]. Finally, a recent study performed on 555 patients from the REALE-ACS registry [15], that enrolled patients undergoing percutaneous coronary intervention for acute coronary syndrome, confirmed a notable predictive value of this score in this clinical setting (AUC 0.71, 95% confidence interval [95%CI] 0.67-0.74) [15].…”

Section: Introductionmentioning

confidence: 99%

Prediction of new-onset atrial fibrillation with the C2HEST score in patients admitted with community-acquired pneumonia

Pastori,

Menichelli,

Romiti

et al. 2024

Infection

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Purpose Patients hospitalized for community-acquired pneumonia (CAP) may have a higher risk of new-onset atrial fibrillation (NOAF). The C2HEST score was developed to evaluate the NOAF risk in the general population. Data on the value of the C2HEST score in acute patients admitted with CAP are lacking. We want to establish the predictive value of C2HEST score for NOAF in patients with CAP. Methods Patients with CAP enrolled in the SIXTUS cohort were enrolled. C2HEST score was calculated at baseline. In-hospital NOAF was recorded. Receiver-operating Characteristic (ROC) curve and multivariable Cox proportional hazard regression analysis were performed. Results We enrolled 473 patients (36% women, mean age 70.6 ± 16.5 years), and 54 NOAF occurred. Patients with NOAF were elderly, more frequently affected by hypertension, heart failure, previous stroke/transient ischemic attack, peripheral artery disease and hyperthyroidism. NOAF patients had also higher CURB-65, PSI class and CHA2DS2-VASc score. The C-index of C2HEST score for NOAF was 0.747 (95% confidence interval [95%CI] 0.705–0.786), higher compared to CURB-65 (0.611, 95%CI 0.566–0.655, p = 0.0016), PSI (0.665, 95%CI 0.621–0.708, p = 0.0199) and CHA2DS2-VASc score (0.696, 95%CI 0.652–0.737, p = 0.0762). The best combination of sensitivity (67%) and specificity (70%) was observed with a C2HEST score ≥ 4. This result was confirmed by the multivariable Cox analysis (Hazard Ratio [HR] for C2HEST score ≥ 4 was 10.7, 95%CI 2.0–57.9; p = 0.006), independently from the severity of pneumonia. Conclusion The C2HEST score was a useful predictive tool to identify patients at higher risk for NOAF during hospitalization for CAP. Clinical Trial Registration www.clinicaltrials.gov (NCT01773863)

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confidence: 99%