Prediction of oral disintegration time of fast disintegrating tablets using texture analyzer and computational optimization

Characterising the disintegration properties of tablets in opaque media using texture analysis

“…This tablet orientation served to increase the surface area of tablet exposed to media when compared to the horizontal tablet orientation used in other studies (Abdelbary et al, 2005;Dor and Fix, 2000;Szakonyi and Zelkó, 2013) so as to more accurately represent the orientation of a tablet during use in a NSDS. Upon probe lowering, the tablet was immersed into 31 mL of media pre-heated to 37 C using a hot plate (Gallenkamp, UK) in a 50 mL beaker.…”

“…Experimental quantitative methods for the characterisation of tablet disintegration time has been developed using a texture analyser (Dor and Fix, 2000;el-Arini and Clas, 2002;Szakonyi and Zelkó, 2013). Disintegration testing via texture analysis could be broadly beneficial for disintegration testing in opaque media since the technique does not require visually assessing completion of tablet disintegration.…”

“…In the constant load technique, the distance travelled by the probe as the tablet disintegrates is recorded (Abdelbary et al, 2005). In the constant velocity technique, a load-displacement curve is generated, from which the in vivo disintegration times have been predicted from an empirical equation (Szakonyi and Zelkó, 2013). Both methods have shown positive correlation with in vivo data (Abdelbary et al, 2005;Dor and Fix, 2000;Szakonyi and Zelkó, 2013).…”

“…In the constant velocity technique, a load-displacement curve is generated, from which the in vivo disintegration times have been predicted from an empirical equation (Szakonyi and Zelkó, 2013). Both methods have shown positive correlation with in vivo data (Abdelbary et al, 2005;Dor and Fix, 2000;Szakonyi and Zelkó, 2013). In this study, the constant load technique is used to characterise tablet disintegration in opaque media.…”

Patient centric formulations for paediatrics and geriatrics: Similarities and differences

“…This is particularly important as the disintegration time is a vital property that affects drug administration and drug release (Pein et al, 2014). Compendial disintegration 245 testing has shown very poor correlation with in vivo disintegration time in the mouth, while novel testing techniques can attain much better correlation (Brniak et al, 2012;Hoashi et al, 2013;Szakonyi and Zelkó, 2013). In addition to fast disintegration other ideal properties include flexibility (in the case of films), physical stability, good handling and suitable mechanical strength (Visser et al, 2015).…”