Prediction of Outcome of Sepsis at Surgical ICU: A Prospective Multi-Center Prospective Study

Salem, Ahmed M.

doi:10.19080/jaicm.2019.08.555743

Cited by 2 publications

(2 citation statements)

References 25 publications

(28 reference statements)

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“…Among the participants in the current study, a considerable correlation was found between the increase in SOFA score and mortality. This discovery aligns with the outcomes documented by Salem et al [23] , wherein they illustrated that the mean SOFA score for survivors was 9.6±1.8, whereas it was 10.5±2.2 for non-survivors. Between the 2 groups, a statistically significant difference in SOFA scores was also noted (p=0.005), according to the study.…”

Section: Discussionsupporting

confidence: 90%

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

Moselhy,

Ghafar,

Alghazaly

et al. 2024

Int. J. Adv. Res. Med.

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Background: Sepsis is a critical medical illness with potentially fatal consequences, prompting the exploration of novel therapeutic interventions aimed at improving patient outcomes. The objective of this study was to assess the influence of administering thiamine and intravenous vitamin C together with hydrocortisone on the prognosis of septic patients in the intensive care unit (ICU). Methods: The current research encompassed 60 patients with sepsis or septic shock into two equal group: the treatment group received intravenous (IV) hydrocortisone, vitamin C and thiamine plus the ordinary medical treatment for sepsis however, the control group received only the ordinary medical. Results: The sepsis related organ failure assessment (SOFA) score was lower in the treatment group compared to the control group, but it didn't reach a significant difference. The mortality rate was lower in the treatment group compared to the control group (46.7% and 63.3%); however, it didn't reach a statistically significant value. With multivariate regression analysis, presence of lower diastolic blood pressure (DBP) and hypertension (HTN) were shown as independent risk factors for mortality. Conclusion:The use of mentioned drugs before did not provide a hastened recovery of septic shock as compared to traditional therapeutic approaches.

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Section: Discussionsupporting

confidence: 90%

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

Moselhy,

Ghafar,

Alghazaly

et al. 2024

Int. J. Adv. Res. Med.

View full text Add to dashboard Cite

show abstract

“…This agreed with Salem et al, who showed that APACHE II score was 22 ± 2.9 and 23.5 ±4 in survivors and non-survivors respectively with statistically significant difference between the two groups (p=0.005). The mean SOFA score was 9.6 ± 1.8 and 10.5 ± 2.2 in survivors and nonsurvivors respectively with statistically significant difference between the two groups ( p=0.005) [27] .…”

Section: Discussionmentioning

confidence: 87%

CURB-65 versus APACHE II as a Prognostic Score to Assess Severity of Sepsis in Critically Ill Geriatric Patients

HAIBA¹,

Mahmoud

2021

The Medical Journal of Cairo University

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Background: Sepsis is a complex condition defined by the systemic response to infection. Severity assessment scoring systems are used to aid the physician in deciding whether aggressive treatment is needed or not. In this study, two severity assessment scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II) and CURB-65 were compared to assess their sensitivity and specificity. Aim of Study:To compare the efficacy between CURB-65 and APACHE II in assessment of the severity of sepsis and predicting mortality in critically ill geriatric patients.Patients and Methods: This prospective comparative study was conducted on patients admitted at Critical Care department of Ain Shams University Hospitals, Cairo, Egypt, for 3 months duration. Patients admitted to the general ICU of Ain Shams University Hospitals with sepsis or septic shock of both sexes Results: The simplicity of calculation of CURB65 demonstrated superiority over other complex severity scores utilized in crowded emergency rooms. Furthermore, the CRB65 score, which does not require a blood urea level, is more suitable for use in gross-roots hospitals. In the current study, CURB-65 score was statistically significantly higher in the non-survivors as compared with the survivors (1.79 ± 1.26 and 0.65±0.43 respectively) (p<0.001). Moreover, in our study, the cutoff point of Curb-65 score to differentiate between non-survivors from survivors was >2 with 59% sensitivity and 92.3% specificity. Unfortunately, no much data is available to describe the prognostic ability of CURB65 in patients with sepsis, as the score was originally developed to assess the prognosis in pneumonia patients. Conclusion:Sepsis is a life threating condition and is one of the leading causes of death. Mortality was reported in 55.7% of patients by the end of the study period. APACHE II was predicting mortality with 84.6% sensitivity and 64.5% specificity, 78.8% PPV & 86.4% NPV and 82.2% accuracy. The length of hospital stay was significantly longer in nonsurvivor group. CURB-65 was statically significantly higher in the non-survivors as compared with the survivors with 59% sensitivity and 92.3% specificity but no much data available to describe prognostic ability of CURB-65 in-patient with sepsis as in pneumonia patients.

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Prediction of Outcome of Sepsis at Surgical ICU: A Prospective Multi-Center Prospective Study

Abstract: The current study supposed that early changes in serum levels of primary phase reactants and copeptin could predict the outcome of patients developed sepsis after admission to ICU.

Cited by 2 publications

References 25 publications

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

The effect of intravenous Vitamin C, thiamine and hydrocortisone on the outcome of septic patients

CURB-65 versus APACHE II as a Prognostic Score to Assess Severity of Sepsis in Critically Ill Geriatric Patients

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