2014
DOI: 10.3797/scipharm.1306-10
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Prediction of Pharmacokinetic Parameters Using a Genetic Algorithm Combined with an Artificial Neural Network for a Series of Alkaloid Drugs

Abstract: An important goal for drug development within the pharmaceutical industry is the application of simple methods to determine human pharmacokinetic parameters. Effective computing tools are able to increase scientists’ ability to make precise selections of chemical compounds in accordance with desired pharmacokinetic and safety profiles. This work presents a method for making predictions of the clearance, plasma protein binding, and volume of distribution for alkaloid drugs. The tools used in this method were ge… Show more

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Cited by 6 publications
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“…Furthermore, ANNs have been successfully used for in vitro release kinetics prediction of active substances from hydrophilic matrix formulations (94,95). Moreover, in the past years, ANNs were combined with various computational tools, e.g., gene algorithms, for the evaluation of the pharmacokinetic parameters of alkaloid drugs (96). RNN has been applied in MPC of CQAs in continuous pharmaceutical manufacturing with favourable results (97).…”
Section: Application Of Artificial Neural Network and Multivariate Data Analysis As Complementary Tools In Pharmaceutical Developmentmentioning
confidence: 99%
“…Furthermore, ANNs have been successfully used for in vitro release kinetics prediction of active substances from hydrophilic matrix formulations (94,95). Moreover, in the past years, ANNs were combined with various computational tools, e.g., gene algorithms, for the evaluation of the pharmacokinetic parameters of alkaloid drugs (96). RNN has been applied in MPC of CQAs in continuous pharmaceutical manufacturing with favourable results (97).…”
Section: Application Of Artificial Neural Network and Multivariate Data Analysis As Complementary Tools In Pharmaceutical Developmentmentioning
confidence: 99%