Prediction of PIH by Maternal Serum Beta HCG Levels in the Second Trimester (13–20 Weeks) of Pregnancy

Kaur, Gurmandeep; Jain, Vimla; Mehta, Sharad; Himani, Sunita

doi:10.1007/s13224-012-0151-y

Cited by 23 publications

(28 citation statements)

References 2 publications

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“…reported a significant lipid profile among prenatal women who subsequently developed hypertension. By contrast, Sorensen et al., Kaur et al., and the present study found that only serum β‐hCG values were higher among pregnant women who developed hypertension. The present findings suggest that serum β‐hCG in early second trimester might be used as a predictor of hypertensive disorders of pregnancy, whereas dyslipidemia would not be a useful marker of hypertension.…”

Section: Discussioncontrasting

confidence: 98%

“…Kaur et al . undertook a study of 200 pregnant women, reporting that 20 of 24 women with elevated β‐hCG (>2 MOM) developed hypertension, but only 2 of 154 women with β‐hCG less than 2 MOM subsequently developed hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…Kaur et al12 undertook a study of 200 pregnant women, reporting that 20 of 24 women with elevated β-hCG (>2 MOM) developed hypertension, but only 2 of 154 women with β-hCG less than 2 MOM subsequently developed hypertension. They reported sensitivity, specificity, and positive predictive values of 90.9%, 97.4%, and 83.3%, respectively, for a β-hCG cutoff level of 60 000 mIU/mL.…”

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confidence: 99%

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Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Revankar

Lavu

2017

Intl J Gynecology & Obste

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Revankar

Lavu

2017

Intl J Gynecology & Obste

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“…This is consistent with the findings of several other studies done in other ethnic group of India. [12][13][14][15] Evidence points to the placenta as a key source of factors that lead to the maternal endothelial cell destruction in preeclampsia. This is already established that the clinical signs and symptoms of pre-eclampsia remit after termination of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Elevated serum ?hCG and dyslipidemia in second trimester as predictors of subsequent Pregnancy Induced Hypertension

Mallick

Ray

Medhi

et al. 2015

Bangladesh Med Res Counc Bull

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Objectives: To test the hypothesis that pregnant women with high serum βhCG level and serum dyslipidemia in second trimester are more prone to develop subsequent Pregnancy Induced Hypertension (PIH). Materials & Methods: One hundred pregnant women with singleton pregnancy between 14 and 20 weeks of gestation attending antenatal outpatient department (OPD) of SMCH were studied. Serum βhCG was estimated by two-site chemiluminescent-immunometric method. Serum lipid profile was evaluated by enzymatic colorimetric test with Lipid Clearing Factor (LCF). Results: Eighteen cases developed PIH while eighty two cases remained normotensive. The serum βhCG level was significantly high (p˂0.001) in those women developing PIH. Serum concentration of total cholesterol in women who subsequently developed PIH was significantly higher than that of normotensive group (p ˂0.05). Mean TG value in PIH group was higher than the normotensive group. Level of LDL in PIH group was also significant (p˂0.05). Conclusion: Present study showed that elevated serum βhCG and Dyslipidemia in second trimester can be considered as predictors of subsequent PIH / Pre-eclampsia. However, there is need of large community based prospective study to validate the result.

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“…It was based on the study conducted by Kaur et al which had the sensitivity of 90.91 %, the specificity of 97.44 % and the positive predictive value of 83.33 % for this cut off value. 4 In their study, 22 cases developed hypertensive disorders among 178 cases. Among 22 cases, 20 cases had β hCG levels > 2 MOM.…”

Section: Serum β Hcg Levels and Pregnancy Outcomementioning

confidence: 94%

Serum β-hcg levels between 12 to 20 weeks of gestation in prediction of hypertensive disordrers of pregnancy

Muthulakshmi

Sasirekha

Rajappa

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONHypertensive disorders of pregnancy (HDP) are unique to pregnancy, affecting 5% to 8% of all pregnant women. In spite of the improvement in maternal and neonatal care, hypertensive disorders of pregnancy are major causes of maternal and perinatal morbidity and mortality in both developed and developing countries. Numerous clinical and biochemical markers have been proposed to predict preeclampsia. As preeclampsia is characterized by disturbed trophoblastic pathology, early placental dysfunction could be reflected by altered hCG concentrations. Therefore, this study is being done to find out the levels of serum β hCG in pregnant women between 12 to 20 ABSTRACT Background: This study was undertaken to study the association of serum β hCG levels between 12 to 20 weeks of gestation and development of hypertensive disorders of pregnancy and to assess the association between the levels of β hCG and severity of hypertensive disorders of pregnancy. Study design: Prospective cohort study (200 uncomplicated primigravida). Methods: All women between 12 to 20 weeks of pregnancy meeting the selection criteria, attended antenatal OPD in JIPMER were recruited for this study after informed consent. The venous blood samples were obtained from the subjects for β-hCG analysis. Serum β hCG level was measured by Enzyme Linked Immunoassay System (ELISA) and expressed as mIU/ml. Multiples of median were calculated from the median of the sample population and were considered as raised if it was >2 MOM. The cases were followed up until delivery and observed for development of hypertensive disorders of pregnancy. Results: Out of 200 cases, 185 cases were followed completely till term. Among 185 cases who were followed up, 10 women developed hypertensive disorders of pregnancy, accounting for 5.4% in the study group. Out of the total 185 women who were studied, 132 had β hCG levels ≤2 MOM and 53 had β hCG levels >2 MOM. Among 132 women (94.7%) with β hCG levels ≤2 MOM, 7 (5.3%) developed hypertensive disorders. Among 53 cases (94.3%) with β hCG levels >2 MOM, 3 women (5.7%) developed hypertensive disorders. The incidence of HDP was almost similar in both the groups, 5.3% among those whose β hCG levels were ≤2MOM and 5.7% among those who had β hCG levels >2 MOM (p value -0.923). Conclusions: From the present study, it may be concluded that high serum β hCG levels (2 MOM) estimated between 12 to 20 weeks of pregnancy were not predictive of development of hypertensive disorders later in pregnancy.

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Prediction of PIH by Maternal Serum Beta HCG Levels in the Second Trimester (13–20 Weeks) of Pregnancy

Cited by 23 publications

References 2 publications

Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy

Elevated serum ?hCG and dyslipidemia in second trimester as predictors of subsequent Pregnancy Induced Hypertension

Serum β-hcg levels between 12 to 20 weeks of gestation in prediction of hypertensive disordrers of pregnancy

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