Prediction of postoperative atrial fibrillation with left atrial mechanical functions and <scp>NT</scp>‐pro <scp>ANP</scp> levels after coronary artery bypass surgery: A three‐dimensional echocardiography study

Hidayet, Şıho; Yağmur, Jülide; Bayramoğlu, Adil; Tasolar, Mehmet Hakan; Kurtoğlu, Ertuğrul; Özyalın, Fatma

doi:10.1111/echo.13833

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…Studies have shown that MR-proANP levels were associated with increased left atrial size, presence of low-voltage areas (LVAs), and AF progression stage. 14,15 Similar findings in terms of left atrial size were also present within our investigation. Previously, a large observational study outlined the importance of MR-proANP in a broad AF population reflecting an increased risk for AF burden and adverse events with increasing plasma values.…”

Section: Pathophysiological Aspects Of Mr-proanpsupporting

confidence: 90%

The Prognostic Potential of Atrial Natriuretic Peptide on the Development of Postoperative Atrial Fibrillation after Cardiac Surgery

et al. 2021

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Background: Post-operative atrial fibrillation (POAF) represents a common complication after cardiac surgery associated with major adverse events and poor patient-outcome. Tools for risk stratification of this arrhythmia remain scarce. Atrial-natriuretic peptide (ANP) represents an easily assessable biomarker picturing atrial function and strain – however, its prognostic potential on the development of POAF has not been investigated so far. Methods: Within the present investigation, 314 patients undergoing elective cardiac surgery were prospectively enrolled. Preoperative MR-proANP values were assessed before the surgical intervention. Patients were followed prospectively and continuously screened for the development of arrhythmic events. Results: A total of 138 individuals (43.9%) developed POAF. Median concentration of MR-proANP were significantly higher within the POAF group (p<0.001). MR-proANP showed a strong association with the development of POAF with a crude odds ratio (OR) of 1.68 per one standard deviation (1-SD; 95%CI 1.31–2.15; p<0.001) which remained stable after comprehensive adjustment for confounders with an adjusted OR of 1.74 per 1-SD (95%CI 1.17–2.58; p=0.006). The discriminatory power of MR-proANP for the development of POAF was validated by the category-free net reclassification improvement (NRI; 0.23 [95%CI: 0.0349 - 0.4193]; p = 0.022) and integrated discrimination increment (IDI; 0.02 [95%CI 0.0046 - 0.0397], p = 0.013). Conclusion: MR-proANP proved to be a strong and independent predictor of the development of POAF. Considering a personalized diagnostic and prognostic pre-operative work up, a standardized pre-operative evaluation of MR-proANP levels might help to identify patients at risk for development of POAF after cardiac surgery.

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Section: Pathophysiological Aspects Of Mr-proanpsupporting

confidence: 90%

The Prognostic Potential of Atrial Natriuretic Peptide on the Development of Postoperative Atrial Fibrillation after Cardiac Surgery

et al. 2021

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“…В нашем исследовании увеличенный диаметр ЛП ассоциировался с риском возникновения ПОФП, что подтверждается результатами литературы [9,10]. ПОФП имеет два основных патофизиологических механизма, которые могут быть связаны с размерами ЛП: дегенеративные изменения миокарда предсердий и предоперационные электрофизиологические изменения.…”

Section: Discussionunclassified

Clinical, echocardiographic parameters and markers of oxidative stress associated with atrial fibrillation in patients undergoing coronary artery bypass graft surgery

Рубаненко¹,

Рубаненко²,

Щукин³

et al. 2020

Russ J Cardiol

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Цель. Оценить взаимосвязь клинических, эхокардиографических показателей и маркеров окислительного стресса с развитием послеоперационной фибрилляции предсердий (ПОФП) у пациентов с ишемической болезнью сердца (ИБС), подвергающихся коронарному шунтированию (КШ). Материал и методы. В рамках исследования "случай-контроль" обследовано 158 пациентов с ИБС, поступивших для проведения КШ. Пациенты разделены на две группы: 1-я группа-без ПОФП (111 больных, 82,0% мужчин, медиана возраста 62,0 [56,0;66,0] года), 2-я группа с ПОФП (47 больных, 84,4% мужчин, медиана возраста 65,0 [61,0;70,0] лет). Медиана развития ПОФП составила 5,2 [2,0;7,0] сут. после КШ. Проводилось исследование содержания супероксиддисмутазы в плазме и в эритроцитах, миелопероксидазы в плазме, каталазы, малонового диальдегида, восстановленного глутатиона (ВГ), глутатионредуктазы (ГР), глутатионпероксидазы (ГПО) в эритроцитах, оксида азота (NO) в плазме, продукты окисления белков. Исследование показателей осуществлялось в предоперационном периоде и в среднем на 3-4 сут. после КШ. Всем пациентам также проводилась эхокардиография. Результаты. После выполнения многофакторного регрессионного анализа отношение шансов развития ПОФП выявлено для следующих показателей: диаметра левого предсердия >41 мм-4,1 (95% доверительный интервал (ДИ),

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“…In a study by Anatolevna et al, left atrial dimensions as well as increased postoperative IL-6, IL-8, and superoxide dismutase were identified as predictors of PoAF (8), while advanced age, low preoperative creatinine clearance, and increased left atrial diameter were reported to be independent predictors of PoAF in the study by Ferreira et al (9). On the other hand Hidayet Ş. et al emphasised that LA volume index (LAVİ) and mechanical functions are better indicator than LA diameter in new onset PAF after CABG (10). Also, vitamin D deficiency was reported to be an independent predictor for PoAF in the study by Emren et al, and increased serum uric acid levels had a predictive role for PoAF in the study by Memetoglu et al (,11,12).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of platelet-lymphocyte ratio in new-onset atrial fibrillation after coronary artery bypass grafting

Ay¹

2019

Kocaeli Med J

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Yüksek trombosit-lenfosit oranının(TLO) sistemik inflamasyon ve kardiyak mortalite ile ilişkisi bilinmektedir. Koroner arter baypas greftleme (KABG) sonrası yeni başlangıçlı atrial fibrilasyon inflamatuvar süreçlerle ilişkilidir. Bu çalışmada bir inflamasyon belirteci olan TLO' nun KABG sonrası yeni başlangıçlı atrial fibrilasyon ile ilişkisi araştırıldı. YÖNTEM ve GEREÇLER: Çalışmaya izole KABG uygulanan 245 hasta dahil edildi. Postoperatif atrial fibrilasyon (AF) gelişen 57(23.1%) hasta (AF grup) ve normal sinüs ritminde (NSR grup) takip edilen 188(76.7%) hasta olmak üzere iki gruba ayrıldı. Gruplar arası klinik ve labaratuvar bulgular karşılaştırıldı. Lojistik regresyon modeli oluşturularak postoperatif AF ile değişkenler arasındaki ilişki araştırıldı. BULGULAR: Yüksek yoğunluklu lipoprotein(HDL) ve lenfosit sayısının NSR grubunda anlamlı düzeyde yüksek olduğu(p<0.05), nötrofil-lenfosit oranının(NLO) ve TLO'nun ise AF grubunda anlamlı düzeyde yüksek olduğu tespit edildi(p<0.05). Multivaryant regresyon analizinde TLO'nun postoperatif AF gelişimi ile ilişkili olduğu tespit edildi(OR: 1.05 CI: 1.01-1.09, p: 0.02). TARTIŞMA ve SONUÇ: Preoperatif TLO'nun KABG sonrası yeni başlangıçlı atrial fibrilasyon için prediktif değeri mevcuttur.

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Prediction of postoperative atrial fibrillation with left atrial mechanical functions and NT‐pro ANP levels after coronary artery bypass surgery: A three‐dimensional echocardiography study

Abstract: It was found that 3D echocardiography can be used as a helping noninvasive method to show subclinical atrial volume and mechanical dysfunction in patients undergoing CABG. Also, blood levels of NT-pro ANP in POAF group were increased.

Cited by 13 publications

References 22 publications

The Prognostic Potential of Atrial Natriuretic Peptide on the Development of Postoperative Atrial Fibrillation after Cardiac Surgery

The Prognostic Potential of Atrial Natriuretic Peptide on the Development of Postoperative Atrial Fibrillation after Cardiac Surgery

Clinical, echocardiographic parameters and markers of oxidative stress associated with atrial fibrillation in patients undergoing coronary artery bypass graft surgery

Predictive value of platelet-lymphocyte ratio in new-onset atrial fibrillation after coronary artery bypass grafting

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