Prediction of postoperative complications and survival after laparoscopic gastrectomy using preoperative Geriatric Nutritional Risk Index in elderly gastric cancer patients

Hirahara, Noriyuki; Tajima, Yoshitsugu; Fujii, Yusuke; Kaji, Shunsuke; Yasunari, Kenichi; Hyakudomi, Ryoji; Yamamoto, Tetsu; Taniura, Takahito

doi:10.1007/s00464-020-07487-7

Cited by 43 publications

(47 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, multivariate analysis identified GNRI as an independent risk factor for CSS. The results obtained in this study are consistent with those shown in previous reports related to lung and gastric cancers [10][11][12]. The TNM staging is useful for predicting the survival in patients with different stages of cancer, but a precise prediction is often difficult among those with the same stage of cancer.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, it has been widely accepted that the GNRI was strongly associated with mortality in elderly hospitalized patients and in patients with various cancers [10][11][12]. However, to the best of our knowledge, there have been few reports on the prognostic significance of the GNRI in patients with esophageal squamous cell carcinoma (ESCC).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

et al. 2020

Self Cite

View full text Add to dashboard Cite

The geriatric nutritional risk index (GNRI) is associated with mortality in several malignancies. We retrospectively analyzed whether the GNRI can predict longterm outcomes in 191 patients with esophageal squamous cell carcinoma (ESCC) after curative esophagectomies by evaluating their cancer-specific survival (CSS). In multivariate analyses, serum albumin (hazard ratio [HR], 2.498; p = 0.0043), GNRI (HR, 1.941; p = 0.0181), pathological tumor-node-metastasis (pTNM) stage (HR, 3.884; p < 0.0001), and tumor differentiation (HR, 2.307; p = 0.0066) were independent prognostic factors for CSS. In pTNM stage I, multivariate analysis identified C-reactive protein (HR, 7.172; p = 0.0483) and GNRI (HR, 5.579; p = 0.0291) as independent prognostic factors for CSS. In univariate analyses in pTNM stages II and III, only low GNRI (p = 0.0095) and low serum albumin levels (p = 0.0119), respectively, were significantly associated with worse CSS. In patients with low GNRI, CSS was significantly worse than in those with normal GNRI (p = 0.0011), especially in pTNM stages I (p = 0.0044) and II (p = 0.0036) groups, but not in stage III group (p = 0.5099). Preoperative GNRI may sort patients into low-or high-risk groups for shorter CSS, especially in those with pTNM stage I and II ESCC.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, intense treatment in subsequent phases, such as the inclusion of adjuvant chemotherapy, better nutritional treatment, or close follow-up, is required for patients in the high-risk group. Malnutrition is a frequent comorbidity in patients with cancer, which is known to be associated with an increased incidence of complications and to have an adverse effect on long-term survival (17,18,20,28). It has been reported that (28).…”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition is a frequent comorbidity in patients with cancer, which is known to be associated with an increased incidence of complications and to have an adverse effect on long-term survival (17,18,20,28). It has been reported that (28). Data from 248 patients with head and neck cancer (17) also showed that patients in the high-risk group had lower threeyear survival rates compared to those in the intermediateand normal-risk groups, and that the decreased GNRI score was significantly associated with an increased risk of mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The GNRI was originally developed to evaluate the nutritional status of elderly patients. Moreover, recent studies have confirmed the utility of GNRI to evaluate prognosis in patients with cancers, including esophageal carcinoma, lung cancer, and head and neck cancer(17)(18)(19)28,31). Hirahara et al evaluated the impact of preoperative GNRI on clinical outcomes in 303 elderly patients with gastric cancer.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Geriatric nutritional risk index as an independent prognostic factor in locally advanced nasopharyngeal carcinoma treated using radical concurrent chemoradiotherapy: a retrospective cohort study

Tang¹,

Qiu²,

Sun³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Nutritional status is a key factor influencing the prognosis of patients with cancer. The Geriatric Nutritional Risk Index (GNRI) has been used to predict mortality risk and long-term outcomes. In this study, we aimed to evaluate the predictive value of pretreatment GNRI in patients with nasopharyngeal carcinoma (NPC).Methods: A total of 1,065 patients with biopsy-proven non-disseminated nasopharyngeal carcinoma were included. Based on a cutoff value of pretreatment GNRI, patients were divided into two groups (low ≤107.7 and high >107.7). Combining GNRI and baseline Epstein-Barr virus (EBV) DNA, all patients were further stratified into three risk groups, namely, high-risk (high EBV DNA and low GNRI), low-risk (low EBV DNA and high GNRI), and medium-risk (except the above) groups. Multivariate analyses were performed using the Cox proportional hazards model to assess the predictive value of the GNRI.Results: Among the 1,065 patients, 527 (49.5%) and 538 (50.5%) were divided into low and high GNRI groups, respectively. Within a median follow-up of 83 months, patients with a high GNRI score exhibited significantly higher overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) compared to those with low GNRI scores (P<0.05). Multivariate analyses revealed that high GNRI is an independent prognostic factor for OS and PFS (hazard ratio, HR, 0.471, 95% CI, 0.270-0.822, P=0.008; HR 0.638, 95% CI, 0.433-0.941, P=0.023, respectively). Using a combination of baseline GNRI and EBV DNA, a satisfying separation of survival curves between different risk groups for OS, PFS, DMFS was observed. The survival rates of patients in the high-risk group were significantly lower than those in the low-and medium-risk groups (all P<0.001). The combined classification was demonstrated to be an independent prognostic factor for OS and PFS after adjustment using multivariate analysis.Conclusions: Pretreatment GNRI is an independent prognostic factor for NPC patients. The combination of baseline GNRI score and EBV DNA level improved the prognostic stratification of

show abstract

Geriatric prognostic scoring system predicts survival after hepatectomy for elderly patients with liver cancer

Sakano,

Noda,

Kobayashi

et al. 2023

Annals of Gastroent Surgery

View full text Add to dashboard Cite

AimThe number of elderly patients with liver cancer is increasing with the aging society. The Geriatric Prognostic Scoring System is useful in predicting the postoperative prognosis for elderly patients with gastrointestinal cancer. The aim of the present study was to assess the predictive ability of the geriatric prognostic scoring system for postoperative survival in elderly patients with liver cancer.MethodsEighty‐eight patients aged ≥75 years who were treated for primary liver cancer and metastatic liver tumor were retrospectively analyzed. The Geriatric Prognostic Score (GPS) was created by several clinical parameters such as age, sex, type of cancer, stage, performance status, body mass index, and comprehensive geriatric assessment. Each patient was divided into two groups of high‐risk to low‐risk according to their GPS: ≧30 high‐risk group and <30 low‐risk. The predictive ability of geriatric prognostic scoring system for postoperative survival was assessed in univariate and multivariate analyses.ResultsOf the 88 patients, 75 were diagnosed as hepatocellular carcinoma and 13 as colorectal liver metastasis. After geriatric prognostic scoring system assessments, 26 patients were diagnosed as high‐risk and the remaining 62 as low‐risk. The 3‐year overall survival rates were 78.5% in the low‐risk group and 35.1% in the high‐risk group (p < 0.001). The univariate and multivariate analyses of overall survival identified high GPS as an independent significant factor (p < 0.001).ConclusionsWe could conclude that the geriatric prognostic scoring system is useful in predicting patients' prognosis after hepatectomy and it can provide helpful information to surgeons for determining treatment strategies for elderly patients with liver cancer.

show abstract

Prediction of postoperative complications and survival after laparoscopic gastrectomy using preoperative Geriatric Nutritional Risk Index in elderly gastric cancer patients

Cited by 43 publications

References 28 publications

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

Geriatric nutritional risk index as an independent prognostic factor in locally advanced nasopharyngeal carcinoma treated using radical concurrent chemoradiotherapy: a retrospective cohort study

Geriatric prognostic scoring system predicts survival after hepatectomy for elderly patients with liver cancer

Contact Info

Product

Resources

About