Prediction of postoperative lower respiratory tract infections in tongue cancer patients based on pretreatment swallowing function

Abstract

Objectives This study investigated the predictive role of pretreatment swallowing function and surgical factors on postoperative and nosocomial lower respiratory tract infections (PN‐LRTIs). Subjects and methods A retrospective study for predicting PN‐LRTIs from January 2017 to December 2018 at Hospital of Stomatology, Sun Yat‐sen University. Patients who were newly diagnosed with tongue squamous cell carcinoma (TSCC) were enrolled. Presurgical swallowing function was assessed using water swallow test (WST) and the M.D. Anderson Dysphagia Inventory (MDADI). Results A total of 83 patients were recruited to the study. Of which 54 were men (65.1%) and 29 were women (34.9%), with the mean age of 51 years old. Thirteen (15.7%) developed PN‐LRTIs. On univariate analysis, the outcomes of WST, the MDADI scores, T stage, tongue resection range, operative time, segmental mandibulectomy, and type of neck dissection exhibited a statistical significance (p < .05). On multivariate analysis, abnormal group of WST (odds ratio [OR], 15.88; 95% CI, 2.13–118.64) and total glossectomy (OR, 12.20; 95% CI, 2.01–68.32) was demonstrated to be independent risk factors. Conclusions The WST together with the resection range of tongue can predict the postoperative risk of PN‐LRTIs collaboratively. Clinically, preventive measures and intensified care should be taken for patients with abnormal WST outcome before surgery and management of total glossectomy.

Significant enhancement of swallowing function and oral hygiene following multidisciplinary team nursing in tongue cancer patients after radical resection

“…Tongue functions, such as chewing, swallowing, and pronunciation, are vital for maintaining a good QoL. Extensive glossectomy can lead to reduced tongue muscle strength, decreased tongue flexibility, and impaired swallowing coordination, resulting in food retention in the throat and an increased risk of aspiration and choking [30].…”

Silencing of SPP1 Suppresses Progression of Tongue Cancer by Mediating the PI3K/Akt Signaling Pathway

“…2 Tongue cancer is more likely to occur in males, and females have a better prognoses than males. 3 The incidence of tongue cancer is presently increasing in many parts of the world, which is mainly related to the external environment and genes of the human body. The external causes of tongue cancer involve an unsanitary diet; often eating hot or irritating food; the influence of denture material; chewing of betel nuts; long-term exposure to cigarette butts; and other harmful substances.…”

Effect of TTLL12 on tubulin tyrosine nitration as a novel target for screening anticancer drugs<em> in&nbsp;vitro</em>

“…Previous studies have focused on OSCC due to its high risk of malignancy, invasion and metastasis ( 14 , 15 ). As it invades adjacent tissues, the tumor has been demonstrated to affect speech, eating, swallowing ( 16 ) and breathing ( 17 ), which causes the quality of life of patients to decrease substantially ( 18 ). Thus, there is an urgent need to identify and develop novel effective treatment for OSCC.…”