The article analyzes the piercing and rolling process of seamless pipes on PRP 70-270 of JSC “VMP” in terms of power parameters, piercing time and geometric sizes of pipes. The research results were compared with the results of computer simulation on software package QFORM 3D. For simulation, the deformation zones were designed for piercing a mold tube with dimensions of 203×16.5 mm in one pass on a mandrel with diameter of 162 mm and in two passes of piercing and rolling-off on mandrels with diameter of 76 and 162 mm, respectively. From the obtained data on the power parameters, it was found that from the point of view of energy consumption, piercing in one pass seems more appropriate. However, when piercing in one pass, wear resistance of the mandrels sharply decreases, since the contact time between the tool and the hot metal increases. This leads to a decrease in quality of the pipes’ inner surface, more frequent replacement of the tool and increased downtime of the equipment. During simulation, the selected parameter of the friction factor has a significant impact on the value of power parameters (torque and power consumption) and piercing time. The dependences of changing power parameters and piercing time on the friction factor during piercing in a two-roll mill with guards are obtained. With increase of the friction factor, piercing time decreases and torque and rolling power increase. The simulation results are correlated with results of experimental rolling. With a correctly chosen value of the friction factor, power parameters and geometry of the mold tube can be quite accurately predicted by computer modeling.