Prediction of pregnancy rate by blastocyst morphological score and age, based on 1,488 single frozen-thawed blastocyst transfer cycles

Goto, Sakae; Kadowaki, Takashi; Tanaka, Satomi; Hagiwara, Hiromi; Kokeguchi, Shoji; Shiotani, Masahide

doi:10.1016/j.fertnstert.2010.06.067

Cited by 85 publications

(67 citation statements)

References 13 publications

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“…In the present study, the relationship between the morphology of the blastocyst inner cell In the present study, cycles were also evaluated based on the woman's age. It has been already reported that the pregnancy rate using blastocyst transfer reduces progressively with increasing patient age (Goto et al, 2011). In a previous retrospective study, low blastocyst formation rate was also observed in advanced age group (Kato et al, 2012).…”

Section: Discussionmentioning

confidence: 83%

Women's age and embryo developmental speed accurately predict clinical pregnancy after single vitrified-warmed blastocyst transfer

Kato

Ueno²,

Yabuuchi³

et al. 2014

Reproductive BioMedicine Online

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The aim of this study is to establish a simple, objective blastocyst grading system using women's age and embryo developmental speed to predict clinical pregnancy following single vitrified-warmed blastocyst transfer (SVBT) by 6-year retrospective cohort study in a private infertility center.A total of 7,341 SVBT cycles divided into 2006-2011 (6,046 cycles) and 2012 cohort (1,295 cycles) were included. Clinical (CPR), ongoing pregnancy (OPR) and delivery rates (DR) were stratified by women's age (<35, 35-37, 38-39, 40-41, 42-45 years) and time to blastocyst expansion (<120, 120-129, 130-139, 140-149, >149 hours) as embryo developmental speed. In all the age groups, CPR, OPR, and DR decreased as the embryo developmental speed decreased (P < 0.0001). A simple 5-grade score based on women's age and embryo developmental speed was determined by actual clinical pregnancy rates observed in the 2006-2011 cohort. Subsequently the novel grading score was validated in the 2012 cohort (1295 cycles) finding an excellent association. In conclusion, in the present study we established a novel blastocyst grading system using women's age and embryo developmental speed as objective parameters.

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Section: Discussionmentioning

confidence: 83%

Women's age and embryo developmental speed accurately predict clinical pregnancy after single vitrified-warmed blastocyst transfer

Kato

Ueno²,

Yabuuchi³

et al. 2014

Reproductive BioMedicine Online

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show abstract

“…Trophoectoderm cells develop into the placenta and their ability to invade the endometrium is the most important step not only for starting the complex process of implantation, but also for maintaining pregnancy and avoiding miscarriage [24]. In this study, trophoectoderm was evaluated as the theoretical TE cell number in the section of the focal plane of the image.…”

Section: Discussionmentioning

confidence: 99%

“…Over the years, various quantitative but mostly qualitative analyses have been made to determine the impact of each blastocyst parameter on IVF outcome [21][22][23][24][25][26][27]. A detailed study was performed by Richter and colleagues in 2001 [28].…”

Section: Introductionmentioning

confidence: 99%

A quantitative approach to blastocyst quality evaluation: morphometric analysis and related IVF outcomes

Lagalla¹,

Barberi²,

Orlando³

et al. 2015

J Assist Reprod Genet

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Purpose To quantify blastocyst morphologic parameters with a feasible and standardized tool, investigating their predictive value on implantation outcome. Method The study retrospectively analyzes 124 blastocysts from 75 patients. Quantitative measurements of blastocyst expansion, inner cell mass and trophoectoderm were taken using digital image analysis software. Result(s) Blastocysts areas were found to be ranging from 11626.2 up to 35076.4 μm 2 . The area of an early blastocyst is A≤18500 μm 2 with a mean diameter d=140±9 μm, and the area of an expanded blastocyst is A≥24000 with d=190 ±9 μm. While blastocyst mean area was not related to implantation rate, more expanded blastocysts displayed a significantly higher implantation rate. Trophoectoderm cell number is a predictor of positive outcome: since a higher of cells (25.6±11.3 vs 16.3±12.8)`forming a tightly knit epithelium is prognostic of implantation potential. Conversely, inner cell mass size is significantly related to implantation only in expanded blastocysts (3122.7±739.0 vs. 2978.1±366.0 μm 2 ). Conclusion(s) Evaluation of blastocyst morphology with a digital image system could be a valuable tool to standardize blastocyst grading based on quantitative parameters. Therefore, digital analysis may be helpful in identifying the best blastocyst to transfer.

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“…The re-expansion grade after warming has been used to indicate blastocyst survivability and quality after vitrification [21][22][23][24][25][26] and the clinical pregnancy rate of rapidly re-expanding blastocysts (within 2-4 h) was more than double the rate of slowly re-expanding blastocysts [21]. In this study, blastocyst degeneration was not observed after TE biopsy and only euploid blastocysts were selected for embryo transfer.…”

Section: Discussionmentioning

confidence: 94%

The optimal timing of blastocyst vitrification after trophectoderm biopsy of preimplantation genetic screening

Lee

2016

Fertility and Sterility

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Prediction of pregnancy rate by blastocyst morphological score and age, based on 1,488 single frozen-thawed blastocyst transfer cycles

Cited by 85 publications

References 13 publications

Women's age and embryo developmental speed accurately predict clinical pregnancy after single vitrified-warmed blastocyst transfer

Women's age and embryo developmental speed accurately predict clinical pregnancy after single vitrified-warmed blastocyst transfer

A quantitative approach to blastocyst quality evaluation: morphometric analysis and related IVF outcomes

The optimal timing of blastocyst vitrification after trophectoderm biopsy of preimplantation genetic screening

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