Prediction of Prognosis for Acute Respiratory Distress Syndrome with Thin-Section CT: Validation in 44 Cases

Abstract

Extensive thin-section CT abnormalities indicative of fibroproliferative changes were independently predictive of poor prognosis in patients with a clinically early stage of ARDS.

Clinical manifestations of dermatomyositis and clinically amyopathic dermatomyositis patients with positive expression of anti–melanoma differentiation–associated gene 5 antibody

“…Traction bronchiolectasis was identified by means of the presence of dilated bronchioles within areas with parenchymal abnormality. Honeycombing was defined as the presence of cystic airspaces measuring 2-10 mm in diameter with well-defined walls (18,19).…”

Detection of Fibroproliferation by Chest High-Resolution CT Scan in Resolving ARDS

“…Completed HRCT scans were evaluated by two chest radiologists using established methods. 8,22 Radiologists had previously calibrated their scoring strategy by concomitantly reading chest HRCT scans obtained early in the study (n 5 8) to ensure consistent grading of subsequently performed HRCT scans. Five levels of imaging were assessed: aortic arch, 1 cm above the dome of the right hemidiaphragm, and three additional levels equally spaced between these two levels.…”

“…Previous investigations have used chest high-resolution CT (HRCT) scans as a tool in very early ARDS ( , 1 week) [7][8][9] to identify patients with fi broproliferative radiologic abnormalities who are likely to suff er poorer short-term outcomes, such as mortality. However, studies to systematically assess fi broproliferation via HRCT scan during resolving ARDS ( .…”

Matrilysin (Matrix Metalloproteinase-7) Regulates Anti-Inflammatory and Antifibrotic Pulmonary Dendritic Cells That Express CD103 (αEβ7-Integrin)

“…2,3 Failure to resolve acute inflammation also contributes to chronic lung injury and pulmonary fibrosis, and the presence of extensive fibrosis may be an independent risk factor that correlates with poor outcome. 4 Impaired epithelial repair contributes to fibrosis in the lung, liver, kidney, and other tissues, 5,6 and epithelial cell interactions with inflammatory and mesenchymal cells are central to both physiological lung repair and pathological lung remodeling.…”