Prediction of Psychosis by Mismatch Negativity

Bodatsch, Mitja; Ruhrmann, Stephan; Wagner, Michael; Müller, Ralf; Schultze‐Lutter, Frauke; Frommann, Ingo; Brinkmeyer, Jürgen; Gäebel, Wolfgang; Maier, Wolfgang; Klosterkötter, Joachim; Brockhaus-Dumke, Anke

doi:10.1016/j.biopsych.2010.09.057

Cited by 266 publications

(283 citation statements)

References 60 publications

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“…The most widely used experimental paradigm to elicit MMN is the oddball paradigm, which involves presenting unexpected, deviant (i.e., "oddball") stimuli amongst an otherwise continuous stream of stimuli and measuring the resulting electrical brain activity using electroencephalography (EEG). Studies indicate that schizophrenia patients show a consistent decrease in the amplitude of the MMN in response to oddball stimuli [117,118] and the MMN impairment is a good candidate as a predictor of the onset of psychosis in UHR patients [119]. These data relating to electrical brain activity indicate a reduced ability to discriminate relevant from irrelevant stimuli in schizophrenia.…”

Section: Possible Phenomenological Correlatesmentioning

confidence: 96%

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Nelson

Sass

2017

Current Problems of Psychiatry

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Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia spectrum disorders. Basic self-disturbance refers to disruption of the sense of ownership of experience and agency of action and is associated with a variety of anomalous subjective experiences. Little is known about the neurocognitive correlates of basic selfdisturbance. In this paper, we review recent phenomenological and neurocognitive research and point to a convergence of these approaches around the concept of self-disturbance. Specifically, we propose that subjective anomalies associated with basic selfdisturbance may be associated with: 1. source monitoring deficits, which may contribute particularly to disturbances of "ownership" and "mineness" (the phenomenological notion of presence) and 2. aberrant salience, and associated disturbances of memory, prediction, and attention processes, which may contribute to hyper-reflexivity, disturbed "grip" or "hold" on the perceptual and conceptual field, and disturbances of intuitive social understanding ("common sense"). These two streams of research are reviewed in turn before considering ways forward in integrative models, particularly regarding the role of early neurodevelopmental disturbances, primary versus secondary disturbances, and the state versus trait nature of such pathology. Empirical studies are required in a variety of populations in order to test the proposed associations between phenomenological and neurocognitive aspects of self-disturbance in schizophrenia. An integration of findings across the phenomenological and neurocognitive domains would represent a significant advance in the understanding of schizophrenia and possibly enhance early identification and intervention strategies.

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Section: Possible Phenomenological Correlatesmentioning

confidence: 96%

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Nelson

Sass

2017

Current Problems of Psychiatry

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“…Targeting CHR individuals for preventive interventions could expose many to unnecessary treatments (with their accompanying side effects), underscoring the need to enhance predictive accuracy with nonclinical measures. In the first of these studies, Bodatsch et al (22) compared CHR participants who did vs. did not convert to psychosis during follow-up. At baseline, converters had significantly smaller MMN amplitude, one comparable to that in earlyillness patients, whereas MMN in nonconverters was comparable to that of healthy age-matched controls.…”

Section: Forecasting the Development Of Psychosis In High-risk Indivimentioning

confidence: 99%

Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders

Light

Näätänen

2013

Proc. Natl. Acad. Sci. U.S.A.

119

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“…This may particularly benefit from a computational modeling approach, which uses physiologically interpretable model parameters for clinical predictions (Stephan et al, 2006). In relation to this, recent studies demonstrated that a reduction of MMN can predict the transition of 'ultra-high risk' to first-episode psychosis (Bodatsch et al, 2010;Shin et al, 2009). Finally, the assessment of the MMN memory trace effect may also provide a promising tool to assess the efficacy of novel pharmacological treatment, in particular for treatment of cognitive impairments.…”

Section: S-ketamine-induced Cognitive Impairmentsmentioning

confidence: 99%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

101

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Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT 2A R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia. Recent theories of psychosis posit that aberrant encoding of prediction errors (PE) may underlie the expression of psychotic symptoms. This study used a roving mismatch negativity (MMN) paradigm to investigate whether the encoding of PE is affected by pharmacological manipulation of NMDAR or 5-HT 2A R, and whether the encoding of PE under placebo can be used to predict drug-induced symptoms. Using a doubleblind within-subject placebo-controlled design, S-ketamine and psilocybin, respectively, were administrated to two groups of healthy subjects. Psychological alterations were assessed using a revised version of the Altered States of Consciousness (ASC-R) questionnaire. As an index of PE, we computed changes in MMN amplitudes as a function of the number of preceding standards (MMN memory trace effect) during a roving paradigm. S-ketamine, but not psilocybin, disrupted PE processing as expressed by a frontally disrupted MMN memory trace effect. Although both drugs produced positive-like symptoms, the extent of PE processing under placebo only correlated significantly with the severity of cognitive impairments induced by S-ketamine. Our results suggest that the NMDAR, but not the 5-HT 2A R system, is implicated in PE processing during the MMN paradigm, and that aberrant PE signaling may contribute to the formation of cognitive impairments. The assessment of the MMN memory trace in schizophrenia may allow detecting early phases of the illness and might also serve to assess the efficacy of novel pharmacological treatments, in particular of cognitive impairments.

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Prediction of Psychosis by Mismatch Negativity

Cited by 266 publications

References 60 publications

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Towards integrating phenomenology and neurocognition: Possible neurocognitive correlates of basic self-disturbance in schizophrenia

Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

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