Prediction of radiation pneumonitis by dose–volume histogram parameters in lung cancer—a systematic review

Rodrigues, George; Lock, Michael; D’Souza, David; Yu, Edward; Dyk, Jake Van

doi:10.1016/j.radonc.2004.02.015

Cited by 396 publications

(257 citation statements)

References 37 publications

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“…The adapted plans (APs) are referred to by the fraction number of the MVCT used to create the merged image, so AP 10 is an adapted plan created using the MVCT from the tenth fraction of treatment. Doses to 99% and 1% of the PTV, along with mean lung dose (MLD) and volume of lung tissue that receives more than 20 Gy (V 20 ), were compared (19,20). Table 1, average initial GTV for the 17 patients was 127 AE 115 (SD) cm 3 .…”

Section: Methodsmentioning

confidence: 99%

Adaptive Radiotherapy Planning on Decreasing Gross Tumor Volumes as Seen on Megavoltage Computed Tomography Images

Woodford

Yartsev

Dar

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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159

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Purpose: To evaluate gross tumor volume (GTV) changes for patients with non-small-cell lung cancer by using daily megavoltage (MV) computed tomography (CT) studies acquired before each treatment fraction on helical tomotherapy and to relate the potential benefit of adaptive image-guided radiotherapy to changes in GTV. Methods and Materials: Seventeen patients were prescribed 30 fractions of radiotherapy on helical tomotherapy for non-small-cell lung cancer at London Regional Cancer Program from Dec 2005 to March 2007. The GTV was contoured on the daily MVCT studies of each patient. Adapted plans were created using merged MVCT-kilovoltage CT image sets to investigate the advantages of replanning for patients with differing GTV regression characteristics.Results: Average GTV change observed over 30 fractions was À38%, ranging from À12 to À87%. No significant correlation was observed between GTV change and patient's physical or tumor features. Patterns of GTV changes in the 17 patients could be divided broadly into three groups with distinctive potential for benefit from adaptive planning. Conclusions: Changes in GTV are difficult to predict quantitatively based on patient or tumor characteristics. If changes occur, there are points in time during the treatment course when it may be appropriate to adapt the plan to improve sparing of normal tissues. If GTV decreases by greater than 30% at any point in the first 20 fractions of treatment, adaptive planning is appropriate to further improve the therapeutic ratio. Ó 2007 Elsevier Inc.

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Section: Methodsmentioning

confidence: 99%

Adaptive Radiotherapy Planning on Decreasing Gross Tumor Volumes as Seen on Megavoltage Computed Tomography Images

Woodford

Yartsev

Dar

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

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159

155

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“…For the prostate plans, these were the maximum bladder, rectum and femoral head doses, as well as the percentage volume of the bladder and rectum receiving 80% of the prescription dose (V 80% ). For the NSCLC plans, the maximum dose to the spinal cord as well as the mean dose to the non-GTV lung (hereafter referred to as "normal lung") and the percentage volume of the normal lung receiving at least 20Gy (V 20 ) [25] were considered. For the parotid plans, the parameters compared were the maximum brain, spinal cord and lens doses and the mean dose to the contralateral parotid gland.…”

Section: Treatment Planningmentioning

confidence: 99%

Clinical implications of the anisotropic analytical algorithm for IMRT treatment planning and verification

Bragg

Wingate

Conway

2008

Radiotherapy and Oncology

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Published paper AbstractPurpose: To determine the implications of the use of the Anisotropic Analytical Algorithm (AAA) for the production and dosimetric verification of IMRT plans for treatments of the prostate, parotid, nasopharynx and lung. Methods: 72 IMRT treatment plans produced using the Pencil Beam Convolution (PBC) algorithm were recalculated using the AAA and the dose distributions compared. 24 of the plans were delivered to inhomogeneous phantoms and verification measurements made using a pinpoint ionisation chamber. The agreement between the AAA and measurement was determined.Results: Small differences were seen in the prostate plans, with the AAA predicting slightly lower minimum PTV doses. In the parotid plans, there were small increases in the lens and contralateral parotid doses while the nasopharyngeal plans revealed a reduction in the volume of the PTV covered by the 95% isodose (the V 95% ) when the AAA was used. Large changes were seen in the lung plans, the AAA predicting reductions in the minimum PTV dose and large reductions in the V 95% . The AAA also predicted small increases in the mean dose to the normal lung and the V 20 . In the verification measurements, all AAA calculations were within 3% or 3.5mm distance to agreement of the measured doses. Conclusions:The AAA should be used in preference to the PBC algorithm for treatments involving low density tissue but this may necessitate re-evaluation of plan acceptability criteria. Improvements to the Multi-Resolution Dose Calculation algorithm used in the inverse planning are required to reduce the convergence error in the presence of lung tissue. There was excellent agreement between the AAA and verification measurements for all sites.3

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“…Thus, volumetric parameters such as V20 (percentage of pulmonary volume receiving ≥ 20 Gy), V10 and V5, and pulmonary mean dose have been shown to be the most important predictive factors for severe pulmonary toxicity. 14,[16][17][18] The lung is the thoracic organ most sensitive to the deleterious effects of radiation, but this does not mean that it is the only limiting anatomical structure to restrict the appropriate dose release. Spinal cord, esophagus, and heart are also restrictive.…”

Section: (B)mentioning

confidence: 99%

Guidelines for the treatment of lung cancer using radiotherapy

Chen

Novaes

Gadia

et al. 2017

Rev. Assoc. Med. Bras.

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Prediction of radiation pneumonitis by dose–volume histogram parameters in lung cancer—a systematic review

Cited by 396 publications

References 37 publications

Adaptive Radiotherapy Planning on Decreasing Gross Tumor Volumes as Seen on Megavoltage Computed Tomography Images

Adaptive Radiotherapy Planning on Decreasing Gross Tumor Volumes as Seen on Megavoltage Computed Tomography Images

Clinical implications of the anisotropic analytical algorithm for IMRT treatment planning and verification

Guidelines for the treatment of lung cancer using radiotherapy

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