Prediction of Recurrent Venous Thromboembolism by Endogenous Thrombin Potential and D-Dimer

Eichinger, Sabine; Hron, Gregor; Kollars, Marietta; Kyrle, Paul A.

doi:10.1373/clinchem.2008.112243

Cited by 128 publications

(123 citation statements)

References 20 publications

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“…Besser et al [92] reported that high ETP measured in the absence of thrombomodulin could indicate the patients at risk of a recurrence especially following an unprovoked episode. Those results were confirmed by Eichinger et al [80].…”

Section: Thrombin Generation As Marker For Recurrence Risksupporting

confidence: 72%

“…As in other studies [92,80] on cohorts with high prevalence of the FV Leiden mutation, no thrombomodulin was added to the thrombin generation assay. This was decided so as not to decrease the sensitivity of the CAT ® assay for recurrent venous thrombosis due to the effect of the common FV Leiden mutation on the assay result (18), as the presence of FV Leiden in its heterozygous variant has not been associated with significant increase in the recurrence risk by most studies in the field [95,96].…”

Section: Discussionmentioning

confidence: 99%

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Thrombin generation in different cohorts: Evaluation of the haemostatic potential

Chaireti¹

2013

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Section: Thrombin Generation As Marker For Recurrence Risksupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Thrombin generation in different cohorts: Evaluation of the haemostatic potential

Chaireti¹

2013

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“…A thrombin generation curve is produced from which parameters such as peak thrombin generation and the area under the thrombin generation curve (the ETP) are derived. Such measures have been used to predict, for example, risk of venous thromboembolism (10). The aim of this investigation was therefore to determine the impact that microparticles have on thrombin generation as measured by the Calibrated Automated Thrombogram V R (CAT) thrombin generation assay.…”

mentioning

confidence: 99%

Flow cytometric analysis of microparticle phenotype and their role in thrombin generation

2010

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Background: Microparticles may be generated from a number of cell types and are known to play a role in haemostasis by a variety of mechanisms. We investigated the role of platelet, red cell, and leucocyte-derived microparticles in the measurement of thrombin generation.Methods: Four parameters of thrombin generation (the endogenous thrombin potential (ETP), lag time, time to peak, peak height) and microparticle content was determined in 35 plasma samples from normal individuals pre and post filtration to remove microparticles. Immunofluorescent flow cytometry was used to identify and enumerate platelet, leucocyte, monocyte and red cell derived microparticles in plasma samples based on the expression of CD42b, CD45, CD15, and Glycophorin A respectively. Expression of phosphatidylserine and tissue factor by microparticles was determined by Annexin V and anti CD142 binding. The pre and post filtration results were compared.Results: There was a significant decrease in ETP and Peak Height, and an increase in the time to peak post filtration (P < 0.001). A significant decrease in the number of CD421, CD451, CD151, CD1421, and Annexin V1 microparticles was also observed. The change in CD42b1 microparticles correlated highly with the change in Annexin V1 microparticles (r 5 0.68). Whilst the change in ETP correlated best with the change in CD151 microparticles (r 5 0.45) and the change in time to peak correlated with the change in Annexin V binding (r 5 0.52) (P < 0.01).Conclusion: The presence of micropartcles in plasma significantly affects thrombin generation. V C 2010

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“…First is the Calibrated Automated Thrombogram (CAT), a plate-based assay that measures the rate of thrombin generation and inhibition in citrated plasma, and has been used to quantify procoagulant activity in several diseases including VTE and coronary artery disease. [8][9][10] The clinical utility of in vitro thrombin generation however, remains to be determined in trauma patients. The objective of this study was to characterize and quantify procoagulant activity and MP in plasma obtained from individuals after traumatic injury.…”

Section: Discussionmentioning

confidence: 99%

Microvesicle Production After Trauma and Its Clinical Impact on Venothromboembolism

Park¹

2011

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Prediction of Recurrent Venous Thromboembolism by Endogenous Thrombin Potential and D-Dimer

Cited by 128 publications

References 20 publications

Thrombin generation in different cohorts: Evaluation of the haemostatic potential

Thrombin generation in different cohorts: Evaluation of the haemostatic potential

Flow cytometric analysis of microparticle phenotype and their role in thrombin generation

Microvesicle Production After Trauma and Its Clinical Impact on Venothromboembolism

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