Prediction of renal cortical defect and scar using neutrophil-to-lymphocyte ratio in children with febrile urinary tract infection

Lee, Jeong Won; Park, Joon Soo; Park, Kyeong Bae; Yoo, Gyeong Hee; Kim, Seung Soo; Lee, Sang Mi

doi:10.3413/nukmed-0878-17-01

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…The utility of the NLR in predicting DMSA scan cortical lesions (indicative of pyelonephritis) was investigated retrospectively in 133 children (0-10 years) with first episode of febrile, microbiologically-confirmed UTI. 41 All patients with prior UTI or urogenital abnormalities other than vesico-ureteric reflux (VUR) were excluded. NLR was higher in patients with a cortical lesion on initial DMSA and was a significant co-variate (OR 1.6, p = 0.007) following logistic regression including age, sex, VUR, WCC and CRP.…”

Section: Urinary Tract Infection (Uti)mentioning

confidence: 99%

“…Findings in the majority of studies have not been replicated or validated in prospective studies. The peripheral blood lymphocyte count can be higher in young children, and this should be considered when interpreting the results of the studies conducted in children (pertussis 40 and UTI 41,42 ). Finally, some studies compare healthy with infected individuals and this is less useful than stratifying within an infection syndrome.…”

Section: Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

Russell

Parajuli

Gale

et al. 2019

Journal of Infection

204

132

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Section: Urinary Tract Infection (Uti)mentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

Russell

Parajuli

Gale

et al. 2019

Journal of Infection

204

132

View full text Add to dashboard Cite

“…[14][15][16] Inflammatory markers are widely found in TC, some of which are involved in cancer development and metastasis. In their evaluation of 151 patients with TC, Lee et al 17 reported significant reductions in NLR after treatment in patients with a low risk of recurrence, patients with stage I disease, and patients who responded well to treatment. These findings suggest the need to further explore the role of inflammatory factors.…”

Section: Introductionmentioning

confidence: 99%

Inflammation Markers Have Important Value in Predicting Relapse in Patients with papillary thyroid carcinoma: A Long-Term Follow-Up Retrospective Study

Huang

Liu

et al. 2022

Cancer Control

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Purpose Many markers of inflammation are increasingly found to have prognostic significance in some cancers. This study investigated the prognostic value of albumin/globulin (AGR), lymphocyte/monocyte ratio (LMR), and other inflammatory markers, including neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), in patients with papillary thyroid carcinoma (PTC). Methods We retrospectively analyzed the data of 764 patients newly diagnosed with PTC (608 women, 156 men) aged 10-83 years. Univariate and multivariate analyses were used to analyze recurrence rates and assess potential prognostic factors. Furthermore, we used random survival forests to construct a random survival forest score (RSFscore). The correlations between various inflammatory factors and traditional prognostic factors were analyzed. We also compared the areas under the curve (AUCs) of the RSFscore and 4 inflammation-based markers. Results AGR, NLR, PLR, and LMR were strongly associated with invasive clinicopathological features (tumor size, lesions, lymph node metastasis, and lymph node metastasis rate) and postoperative recurrence. In the multivariate analysis, AGR and LMR were independent prognostic markers for recurrent PTC. Higher NLR and PLR values indicated a higher risk of recurrence, while higher LMR and AGR values suggested a lower recurrence risk. The predictive power of the combined indicators was stronger than that of single indicators alone. Conclusion Compared to the analysis of a single indicator, the combination of inflammatory markers was more helpful in determining the risk of PTC recurrence, which has an important impact on predicting patients’ cancer-free survival and quality of life.

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“…SII might be used as an additional parameter in the prediction of renal involvement in newborns with UTIs (34). Lee et al (35) found that NLR was signi cantly associated with persistent cortical defect on the follow-up DMSA scan and positive cortical defect on the initial scan in patients without VUR in children with febrile UTI. In current study, NLR and SII was higher, and PLR was lower in positive urine culture group than negative urine culture group.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of new generation immune-systemic inflammation markers to predict of urine culture growth in urinary tract infection in children

Elgormus,

Okuyan,

Dumur

et al. 2023

Preprint

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Objective Systemic inflammation has been implicated in urinary tract infection (UTI) development and progression. Accordingly, the aim of this study was to determine whether the white blood cell (WBC), the C-reactive protein (CRP), the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and the systemic immune-inflammation index (SII) are useful markers to predict of urine culture growth in children with UTI. Secondly, it was also to evaluate the prevalence of UTI pathogens, antibiotic resistance patterns, and empirical treatment options in children diagnosed with UTI by laboratory and clinical findings. Method Study population comprised 413 cases (positive urine culture) and 318 cases (negative urine culture) with UTI. Results There was no statistically significant difference in the medians of hemoglobin (HGB), hematocrit (HCT) and platelet (PLT) between the negative and positive culture groups. The median of monocytes, WBC, NLR, SII and CRP of the patients have positive urine culture was statistically significantly higher than the negative urine culture group. The AUC value was 0.747 (0.710–0.784) for CRP with a cut-off value of 3.2, the sensitivity is 56.4% and specificity is 98.4% in terms of UTI. The AUC value was 0.733 (0.697–0.769) for SII with a cut off value of 600, the sensitivity is 58.4% and the specificity is 83.0%. The AUC value was 0.732 (0.697–0.769) for NLR with a cut off value of 2, the sensitivity is 57.4% and the specificity is 81.1%. Conclusion WBC, CRP, NLR, PLR and SII may a useful independent diagnostic or complementary marker for disease in children diagnosed with UTI have positive urine culture. E. coli was the most common causative agent, the most used antibiotic is cephalosporin, high resistance to cefuroxime, trimethoprim-sulfamethoxazole (TMP-SMX), cefixime, ampicillin, and ceftriaxone was detected in all agents of UTIs in childhood in our center.

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Prediction of renal cortical defect and scar using neutrophil-to-lymphocyte ratio in children with febrile urinary tract infection

Abstract: NLR was significantly associated with persistent cortical defect on follow-up DMSA scan in patients without VUR, as well as positive cortical defect on initial scan.

Cited by 12 publications

References 21 publications

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

Inflammation Markers Have Important Value in Predicting Relapse in Patients with papillary thyroid carcinoma: A Long-Term Follow-Up Retrospective Study

Evaluation of new generation immune-systemic inflammation markers to predict of urine culture growth in urinary tract infection in children

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