Prediction of Response in Head and Neck Tumor: Focus on Main Hot Topics in Research

Belgioia, Liliana; Morbelli, Silvia; Corvò, Renzo

doi:10.3389/fonc.2020.604965

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…Finally, immune modulation is further supported by MDSCs secretion of IL-1 and IL-6, which impairs APCs maturation and favors T-regs development [ 28 , 29 , 30 , 31 ]. T-regs increase has been proved both in TILs and circulating T-cells of HNSCC compared with healthy donors and has been associated with the upregulation of immune checkpoint molecules such as PD1, PDL1, and CTLA4 [ 33 , 34 , 35 ]. Therefore, the presence of an immunosuppressive microenvironment in HNSCC represents a critical issue to overcome.…”

Section: Treatment-induced Modifications Of the Tumor Microenvironmentmentioning

confidence: 99%

“…MDSCs and CAFs exert immune suppressive roles both by decreasing the activity of immunostimulatory cells and recruiting immunosuppressive cells represented by Tregs and TAM M2. The latter produce immunosuppressive cytokines such as IL-10 and TGF-beta, which in turn further increase MDSCs within the TME and suppress T-cells functions [ 28 , 29 , 30 , 31 , 32 ] ( b ) T-regs are remarkably increased in TME of HNSCC and they show an upregulation of immune checkpoint molecules, namely PD-1, PD-L1, and CTLA-4 [ 33 , 34 , 35 ]. PD-1 expression is also increased on T CD8+ cells in HNSCCs [ 29 , 30 ].…”

Section: Figurementioning

confidence: 99%

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The Histological Background of Recurrence in Laryngeal Squamous Cell Carcinoma: An Insight into the Modifications of Tumor Microenvironment

Arcovito

Palomba

Gallo

et al. 2023

Cancers

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Recurrent laryngeal carcinoma presents differences from the primary tumor that largely depend on the treatment. In this article, we review the histologic and molecular treatment-induced changes that may affect the diagnosis of recurrent laryngeal carcinoma, the assessment of predictive markers, and the response to treatment with immune checkpoint inhibitors. Radiotherapy induces profound modifications that are strictly related to necrosis of different tissue components, fibrosis, and damage of the tumor vessels. Postradiotherapy recurrent/persistent laryngeal squamous cell carcinoma typically presents a discohesive growth pattern within a fibrotic background associated with significant changes of the tumor immune microenvironment, with both important immunosuppressive and immunostimulatory effects. Overall, the increase of immunoregulatory cells and immune checkpoints such as CTLA-4, TIM-3, PD-1, and PD-L1 induced by radiotherapy and chemotherapy strongly supports the use of immune checkpoint inhibitors in recurrent/persistent laryngeal carcinoma. Future studies aiming to identify predictive factors of the response to immune checkpoint inhibitors should consider such treatment-induced modifications.

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Section: Treatment-induced Modifications Of the Tumor Microenvironmentmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

The Histological Background of Recurrence in Laryngeal Squamous Cell Carcinoma: An Insight into the Modifications of Tumor Microenvironment

Arcovito

Palomba

Gallo

et al. 2023

Cancers

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“…Though there is a relatively increased understanding on the key factors leading to head and neck cancers, several studies have emphasized on the role of early diagnostic, predictive and prognostic biomarkers for improving survival rates in HNC patients (3)(4)(5)(6). Recent advances in technologies have helped to understand molecular, metabolic, genetic and proteomic landscape of HNC.…”

Section: Introductionmentioning

confidence: 99%

Editorial: Genomics, proteomics and immunological signatures as diagnostic, predictive, and prognostic biomarkers in head and neck cancers

2023

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“…Some factors associated with a poor RT response in HNSCC include HPV-negative status and hypoxia [ 18 ]. Oral cavity cancer has among the worst clinical outcomes of upper aerodigestive tract tumors and a worse response to primary treatment with RT compared to surgical series [ 5 , 19 ], leading to it being primarily considered a surgical disease.…”

Section: Introductionmentioning

confidence: 99%

Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers

Dhakal

Upadhyay

Wheeler

et al. 2022

IJMS

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Purpose/Objective(s): Microbiome has been shown to affect tumorigenesis by promoting inflammation. However, the association between the upper aerodigestive microbiome and head and neck squamous cell carcinoma (HNSCC) is not well established. Hypoxia is a modifiable factor associated with poor radiation response. Our study analyzed the HNSCC tumor samples from The Cancer Genome Atlas (TCGA) to investigate the relationship between different HNSCC tumor subsites, hypoxia, and local tumor microbiome composition. Results: A total of 357 patients were included [Oral cavity (OC) = 226, Oropharynx (OPx) = 53, and Larynx/Hypopharynx (LHPx) = 78], of which 12.8%, 71.7%, and 10.3%, respectively, were HPV positive. The mean (SD) hypoxia scores were 30.18 (11.10), 24.31 (14.13), and 29.53 (12.61) in OC, OPx, and LHPx tumors, respectively, with higher values indicating greater hypoxia. The hypoxia score was significantly higher for OC tumors compared to OPx (p = 0.044) and LHPx (p = 0.002). There was no significant correlation between hypoxia and HPV status. Pseudomonas sp. in OC, Actinomyces sp. and Sulfurimonas sp. in OPx, and Filifactor, Pseudomonas and Actinomyces sp. in LHPx had the strongest association with the hypoxia score. Materials/Methods: Tumor RNAseq samples from TCGA were processed, and the R package “tmesig” was used to calculate gene expression signature, including the Buffa hypoxia (BH) score, a validated hypoxia signature using 52 hypoxia-regulated genes. Microbe relative abundances were modeled with primary tumor location and a high vs. low tertile BH score applying a gamma-distributed generalized linear regression using the “stats” package in R, with adjusted p-value < 0.05 considered significant. Conclusions: In our study, oral cavity tumors were found to be more hypoxic compared to other head and neck subsites, which could potentially contribute to their radiation resistance. For each subsite, distinct microbial populations were over-represented in hypoxic tumors in a subsite-specific manner. Further studies focusing on an association between microbiome, hypoxia, and patient outcomes are warranted.

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Prediction of Response in Head and Neck Tumor: Focus on Main Hot Topics in Research

Cited by 6 publications

References 62 publications

The Histological Background of Recurrence in Laryngeal Squamous Cell Carcinoma: An Insight into the Modifications of Tumor Microenvironment

The Histological Background of Recurrence in Laryngeal Squamous Cell Carcinoma: An Insight into the Modifications of Tumor Microenvironment

Editorial: Genomics, proteomics and immunological signatures as diagnostic, predictive, and prognostic biomarkers in head and neck cancers

Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers

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