Prediction of Response to Cardiac Resynchronization Therapy: The Selection of Candidates for CRT (SCART) Study

Achilli, Augusto; Peraldo, Carlo; Sassara, Massimo; Orazi, Serafino; Bianchi, Stefano; Laurenzi, Francesco; Donati, Roberto; Perego, Giovanni Battista; Spampinato, A.; Valsecchi, Sergio; Denaro, Alessandra; Puglisi, Andrea

doi:10.1111/j.1540-8159.2006.00486.x

Cited by 144 publications

(66 citation statements)

References 39 publications

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“…Although 2 multicenter trials showed that the values >44ms (by SCART group) and 49.2ms (by CARE-HF group) are predictor of echocardiographic response and event free curves after CRT (19,20), in large prospective studies using pulsed wave Doppler, IVDys was not predictive for the effect of CRT (10,12).…”

Section: Interventricular Dysynchronymentioning

confidence: 99%

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Gürel¹,

Tigen²

2011

Anadolu Kardiyol Derg

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ÖZETKardiyak resenkronizasyon tedavisi (KRT) ventrikül içi ileti gecikmesi olan hastalar için önemli bir tedavi seçeneği olup, seçilmiş kalp yetmezliği hastalarında mortalite ve morbiditeyi azalttığı gösterilmiştir. Ventrikül içi gecikmeyi tanımlamak ve KRT adaylarını seçmek için, renkli doku Doppler ekokardiyografi ve benek takibi gibi, çeşitli ekokardiyografik yöntemler önerilmiştir. Bu dikkatlice seçilmiş hastaların yaklaşık %30'u yanıt vermediğine göre, KRT'ne yanıtın öngörücüleri hala araştırma konusu olarak kalmaya devam etmektedir. Son zamanlarda kardiyak manyetik rezonans (KMR) görüntülemelerdeki geç gadolinyum tutulumu tarafından gösterilen miyokardiyal fibrozis, hem intraventriküler dissenkroninin hem de KRT'ne cevabın gelecek vadeden öngörücüsü olarak gösterilmiştir. Bu derlemenin konusu, KRT adaylarını seçmede kullanılan majör ekokardiyografik yön-temler, bu konuda KMR tarafından saptanan kardiyak fibrozisin potansiyel rolü ve kardiyak fibrozisin intraventriküler dissenkroni varlığıyla muhtemel ilişkisidir. ( ABSTRACTCardiac resynchronization therapy (CRT) is an important therapeutic option for patients with intraventricular conduction delay and has been shown to reduce mortality and morbidity in selected heart failure patients. Several echocardiographic methods have been proposed to define intraventricular delay and to select candidates for CRT, such as color coded tissue Doppler echocardiography and speckle tracking. Since, up to 30% of these carefully selected patients do not receive benefit; predictors of response to CRT still remain a topic of ongoing investigations. Recently, myocardial fibrosis defined by late gadolinium enhancement on cardiac magnetic resonance (CMR) imaging has been introduced as promising predictor of both intraventricular dyssynchrony and response to CRT. The focus of the present review is the major echocardiographic modalities to select CRT candidates, the potential role of cardiac fibrosis detected by CMR in this respect, and the possible relation of it with the presence of intraventricular dyssynchrony.

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Section: Interventricular Dysynchronymentioning

confidence: 99%

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Gürel¹,

Tigen²

2011

Anadolu Kardiyol Derg

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“…M-mode-based variables such as septal-to-posterior wall motion delay have been shown to not be significantly different between responders and nonresponders (23,24). Several other studies have reported the poor predictive value of other variables derived from 2DE platforms (21,25,26). In particular, the recently published PROSPECT trial results highlighted the poor predictive value and significant variability in measuring mechanical dyssynchrony using 12 two-dimensional tissue Doppler-derived parameters (21).…”

Section: Discussionmentioning

confidence: 99%

Utility of three-dimensional echocardiography in assessing and predicting response to cardiac resynchronization therapy

Lau

Abdel‐Qadir

Lashevsky

et al. 2010

Canadian Journal of Cardiology

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“…Since only 70-80% of chronic heart failure patients receiving CRT respond to this therapy [1][2][3][4][5], better methods for prediction of response are mandatory. Mechanical dyssynchrony in LV contraction is thought to predict the response to CRT better than electrical dyssynchrony [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Relation between three-dimensional echocardiography derived left ventricular volume and MRI derived circumferential strain in patients eligible for cardiac resynchronization therapy

Rüssel

Dijk

Kleijn

et al. 2008

Int J Cardiovasc Imaging

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Objectives To compare regional left ventricular (LV) volume curves obtained with real time three-dimensional echocardiography (RT3DE) with two-dimensional circumferential strain curves obtained by MRI in cardiac resynchronization therapy candidates. Background Several methods using either ultrasound or MRI are used to quantify mechanical dyssynchrony (MD). Theoretically, LV volume and circumferential strain seem related, since both measures are connected to the radius of the ventricle. Methods In 21 patients with chronic heart failure, RT3DE and tagged MRI were performed subsequently. Regional LV volume was computed from the ultrasound images. From the MR images, regional circumferential strain was calculated. Cross-correlations with time lags of 1% of the cardiac cycle were performed to compare the curves in corresponding LV segments. Furthermore, peak septal to lateral (SL) delays were compared between modalities. Results High correlations were found between the curves (r 2 = 0.65 ± 0.19), but regional differences in time delay between modalities were observed. In the septum, the volume curve was earlier than the strain curve by 1.8 ± 17.0 time-lags (n.s.), while in the lateral wall, the volume curve was earlier by 3.3 ± 12.0 time-lags (P \ 0.02). There was a non-significant difference between SL delays in the two modalities (volume: -1.0 ± 8.6%, strain: 3.0 ± 12.7%, P = 0.17, a positive sign indicates that the lateral wall is delayed). Conclusions High correlations were observed between both modalities, but regional differences in time-delay were found. This is possibly inherent to the method of echocardiographic volume calculation and hampers the comparison of both measures for the quantification of MD.

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Prediction of Response to Cardiac Resynchronization Therapy: The Selection of Candidates for CRT (SCART) Study

Cited by 144 publications

References 39 publications

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Utility of three-dimensional echocardiography in assessing and predicting response to cardiac resynchronization therapy

Relation between three-dimensional echocardiography derived left ventricular volume and MRI derived circumferential strain in patients eligible for cardiac resynchronization therapy

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