Prediction of risk of osteoporosis after gastrectomy for gastric cancer

Abstract

Introduction There are few guidelines for screening of osteoporosis in patients who have undergone gastrectomy. This study aimed to develop and validate a nomogram to predict the risk of osteoporosis after gastrectomy in patients with gastric cancer. Methods Bone densitometry results for 522 patients with gastric cancer and 2088 individuals from a health-promotion centre were compared using propensity score matching to develop a nomogram to predict osteoporosis after gastrectomy. External validation was performed using an independent data set. Results In the 10 years after gastrectomy 53.5 per cent of patients developed osteoporosis. In multivariable analysis, the odds ratios of subtotal gastrectomy and total gastrectomy were 5.46 and 8.69 (P < 0.001 for both). Seven risk factors (type of gastrectomy, age, sex, BMI, and serum levels of albumin, creatinine and phosphorus) were incorporated into the nomogram. The prediction accuracy of the nomogram in the development set was 0.830 (area under the curve (AUC)); (95 per cent c.i. 0.812 to 0.848). In the validation set, the AUC was 0.807 (95 per cent c.i. 0.741 to 0.873). Conclusion Gastrectomy was a risk factor for osteoporosis, and its incidence in the first 10 years after surgery was high. This nomogram can help clinicians to identify patients with gastric cancer most at risk of developing osteoporosis after surgery.

Case Report: Severe osteoporosis misunderstood by bone metastasis after total gastrectomy and multiple metastasectomy

“…In addition, studies have been conducted to predict risk factors for osteoporosis. Recently, a nomogram has been developed to predict the risk of osteoporosis after gastrectomy for gastric cancer (21). However, we did not find any cases of severe osteoporosis that were misunderstood as recurrence due to a history of multiple surgeries for gastric cancer recurrence.…”

Preoperative abnormal bone mineral density as a prognostic indicator in patients undergoing gastrectomy for gastric cancer: A cohort study

“…One potential explanation for this observation could be the transition from normal BMD (HU > 110) pre-gastrectomy to abnormal BMD (HU ≤ 110) postgastrectomy. [30,[42][43][44][45] This shift underscores the potential impact of gastrectomy on bone health, with studies a significant prevalence of osteoporosis development following gastrectomy. For instance, Park et al observed that within 10 years after gastrectomy, 53.5% of patients developed osteoporosis, [42] while Yoo et al reported a 34.0% prevalence of osteoporosis during a median follow-up of 6.0 years.…”

“…[30,[42][43][44][45] This shift underscores the potential impact of gastrectomy on bone health, with studies a significant prevalence of osteoporosis development following gastrectomy. For instance, Park et al observed that within 10 years after gastrectomy, 53.5% of patients developed osteoporosis, [42] while Yoo et al reported a 34.0% prevalence of osteoporosis during a median follow-up of 6.0 years. [44] Total gastrectomy may carry a heightened risk of osteoporosis compared to partial gastrectomy.…”

Osteoporosis Risk Prediction Using Enhanced Support Vector Machine over Artificial Neural Network

“…Essential bone malignancy starts in the cells of the bones. Tumor cells are bone cells that have shown to be harmful (Park et al 2021; Tang, Han, and Yin 2022) The information in this segment is all about the importance of bone growth. The vast majority of persons who have tumor cells in their bones do not build their bones properly.…”

“…They have cancer cells in their bones that have spread from a tumor somewhere else in their bodies. (Park et al 2021) This disorder is known as auxiliary or metastatic bone disease.Finally, we discuss future research to improve accuracy using the ANN model. In my opinion the above most cited article is best compared to the other articles.…”