Prediction of Severity of Acute Pancreatitis Using Total Serum Calcium and Albumin-Corrected Calcium: A Prospective Study in Tertiary Center Hospital in Nepal

Pokharel, Ashik; Sigdel, Prem Raj; Phuyal, Suman; Кансакар, Прасан; Vaidya, Pradeep

doi:10.1155/2017/1869091

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…In this work, age, sex and etiology of AP were statistically non-significant different between both groups. This agrees with Pokharel et al [14] who reported that the severity of AP was not related to the age or sex of the patient. Similarly, there was no association between etiology and severity of AP.…”

Section: Discussionsupporting

confidence: 93%

Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis

Gadallah,

Saad,

Elsawy

et al. 2023

Int. J. Adv. Res. Med.

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Background: Reduced morbidity and mortality may be achieved with prompt detection of severe acute pancreatitis (AP). The purpose of this research is to demonstrate a connection between AP severity and the Triglyceride glucose (TYG) index. Methods: This research included 60 individuals who met the clinical criteria for AP and was an observational prospective cohort. Two categories of patients were identified: the severe group (n = 17) and the non-severe group (n = 43). For each patient, the TYG index was computed as follows: ln [fasting plasma glucose (mg (dL) × fasting TG (mg/dL)]\2. Results: TYG index was significantly higher in severe group. TYG index can significantly predict severity of AP (P=0.002 and AUC = 0.741) at cut-off >5.16 with 76.47% sensitivity, 72.09% specificity, 68.9% PPV and 78.2% NPV. Conclusions:The results of this research indicate that the TYG index exhibits independent prognostic value in individuals diagnosed with AP. Furthermore, we propose that the TYG index serve as a prognostic tool for SAP when a cut-off value of >5.16 is used. The sensitivity of this cut-off value is determined to be 76.47%, while the specificity is 72.09%. Additionally, the positive predictive value (PPV) is calculated to be 68.9%, and the negative predictive value (NPV) is determined to be 78.2%. There is a direct link between the frequency of SAP and AP-related problems and a high TYG index.

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Section: Discussionsupporting

confidence: 93%

Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis

Gadallah,

Saad,

Elsawy

et al. 2023

Int. J. Adv. Res. Med.

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“…Although studies on AP have been conducted in Nepal, there is no study that has examined FS among patients with AP. A previous study from our center noted biochemical markers, total serum calcium and albumin-corrected calcium, are useful severity predictors in AP [ 18 ]. Our study further adds that median FS 48 is a useful parameter as increased median FS 48 was observed in more severe AP.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Fluid Sequestration in Patients with Acute Pancreatitis: A Prospective Study in Tertiary Centre Hospital in Nepal

Bhandari

Sapkota

Subedi

et al. 2021

Gastroenterology Research and Practice

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Background. Acute pancreatitis (AP) is associated with extensive fluid sequestration. The aim of this study was to determine association of fluid sequestration at 48 hours after hospital admission (FS48) in AP patients with demographics, clinical parameters, and outcomes of AP. Methods. A prospective observational study was carried out on all adult patients with AP admitted to Tribhuvan University Teaching Hospital, Nepal, from January to September 2017. FS48 was calculated as the difference between fluid input and output in the first 48 hours of admission. The Kruskal-Wallis test with post hoc Dunn’s test examined the difference in FS48 between mild AP, moderately severe AP, and severe AP. Linear regression analysis was used to evaluate association between FS48 with patients’ characteristics and outcomes of AP. Outcomes of AP assessed included pancreatic necrosis, persistent organ failure, length of stay, and in-hospital mortality. Results. Eighty patients (median age 44 years; 57% male) with a median FS48 of 1610 mL were evaluated. The median FS48 for mild AP, moderately severe AP, and severe AP were 1,180 mL, 2,380 mL, and 3,500 mL, respectively. There was a significant difference in pairwise comparisons between mild AP and moderately severe AP, along with mild AP and severe AP. Younger age, other etiology, and higher creatinine were independently associated with increased FS48. Increased FS48 was significantly associated with pancreatic necrosis, persistent organ failure, and in-hospital mortality. Conclusions. In our study population, younger age and higher creatinine were predictors of increased FS48. Increased FS48 was associated with poorer outcomes of AP.

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“…When comparing the sensitivity, specificity, and predictive values of Total calcium to those of [3] we found that our sensitivity was significantly greater. The higher cutoff value could explain the improved [16,15]. so, determination of serum calcium levels is a direct biochemical measure that is regularly performed in the majority of hospital settings.…”

Section: Discussionmentioning

confidence: 99%

To Study the Association of Total Serum Calcium Level in Assessing the Severity of Pancreatitis

Kumar

Sundaram

2021

JPRI

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Background: Pancreatitis is an inflammatory condition that affects the pancreas and may also affect other tissues or distant organ. In this study our aim is to see if blood calcium level can be used as a prognostic marker in determining the severity of acute pancreatitis because hypocalcaemia is linked to higher mortality and hospitalization. Method: A retrospective study was conducted in the medical records department of a tertiary care health facility. A total of 75 participants were included in the research. .demographic details of all patients were collected .Patients above 18 years who presented with of epigastric pain, pre-Diagnosed gallstones, alcoholism were included int this study. The lowest total calcium levels were collected in order to examine total calcium as a predictive factor for severity. All of these information were collected and analyzed to get the appropriate findings. Results: A total of 75 patients were included in the research. The age of patients in each severity grade did not differ significantly (p value>0.05). The gender distribution of the two groups did not differ. (P >0.05). For mild and severe acute pancreatitis, mean total calcium levels were 7.98 and 6.67, respectively, which was statistically significant (p< 0.05). Conclusion: The total serum calcium level is a useful indicator for assessing pancreatitis.

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Prediction of Severity of Acute Pancreatitis Using Total Serum Calcium and Albumin-Corrected Calcium: A Prospective Study in Tertiary Center Hospital in Nepal

Cited by 12 publications

References 18 publications

Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis

Triglyceride glucose index as a novel biomarker to identify severity of acute pancreatitis

Factors Associated with Fluid Sequestration in Patients with Acute Pancreatitis: A Prospective Study in Tertiary Centre Hospital in Nepal

To Study the Association of Total Serum Calcium Level in Assessing the Severity of Pancreatitis

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