In this paper, the factor of safety values of soil against liquefaction (FS) were investigated by mean of artificial neural network (ANN) and multiple regression (MR). To achieve this, two earthquake parameters, namely, earthquake magnitude (M w ) and horizontal peak ground acceleration (a max ), and six soil properties, namely, standard penetration test number (SPT-N), saturated unit weight (γ sat ), natural unit weight (γ n ), fines content (FC), the depth of ground water level (GWL), and the depth of the soil (d) varied in the liquefaction analysis and then the FS value was calculated from the simplified method for each case by using the Excel program developed and utilized in the simulation of the feed forward ANN model with back propagation algorithm and the MR model. The FS values predicted from both ANN and MR models were contrasted with those calculated from the simplified method.In additionally, five different performance indices were used to evaluate the predictabilities of the models developed. These performance indices indicated that the ANN models is superior to the MR model in predicting the FS value of the soil.