Brain Strokes are considered one of the deadliest brain diseases due to their sudden occurrence, so predicting their occurrence and treating the factors may reduce their risk. This paper aimed to propose a brain stroke prediction model using machine learning classifiers and a stacking ensemble classifier. The smote technique was employed for data balancing, and the standardization technique was for data scaling. The classifiers' best parameters were chosen using the hyperparameter tuning technique. The proposed stacking prediction model was created by combining Random Forest (RF), K-Nearest Neighbors (KNN), Logistic Regression (LR), Support Vector Machine (SVM), and Naive Bayes (NB) as base classifiers, and meta learner was chosen to be Random Forest. The performance of the proposed stacking model has been evaluated using Accuracy, Precision, Recall, and F1 score. In addition, the Matthews Correlation Coefficient (MCC) has been also used for more reliable evaluation when having an unbalanced dataset, which is the case in most medical datasets. The results demonstrate that the proposed stacking model outperforms the standalone classifiers by achieving an accuracy of 97% and an MCC value of 94%.