Prediction of success in assisted reproductive technology with the help of morphology of the testis

Кульченко, Н. Г.

doi:10.17709/2409-2231-2018-5-4-2

Cited by 8 publications

(5 citation statements)

References 12 publications

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“…Diagnosis of genetic abnormalities is extremely important in the examination of patients with male infertility in order to assess the success of assisted reproductive technologies (ART) [2,7]. Syndromic genetic mutations are often the cause of azoospermia.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis of geneticforms of azoospermia

Sturov¹,

Myandina²,

Saushev³

et al. 2019

AREM

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I n t R o D U C t I o nReduced sperm fertility occurs on average in 7% of men in the population [2,7]. As a rule, laboratory and instrumental signs of male infertility are semen disorders that are quantitative and qualitative [2]. Male infertility is a polyetiological disease [1], which may be due to genetic factors. Genetic abnormalities are available azoospermia in 30-50% of patients [5,6,8].It is known that there are several genetic causes of male infertility: chromosomal disruptions (Robertson translocations, structural changes in the karyotype, inversions); abnormal number of chromosomes (chromosomal disomy, development of Klinefelter syndrome); the appearance of fallen chromosomal sites (deletions) in the AZF locus of the Y chromosome; microdeletions and point mutations in the androgen receptor (AR) gene; abnormalities in the structure of sex chromosomes (local mutations) [3,4]. Aim.Identify the main genetic causes of azoospermia. a B s t r a C t -Aim: To identify the main genetic causes of azoospermia. Methods. The study included 92 patients with azoospermia. In all patients we carried out genetic tests -karyotyping, PCRdiagnosis of blood. Results. Genetic disorders were found in 35 (38%) men. Of these, the majority of men were with Kleinfelter syndrome -21 (60%) and deletions in the AZF regions of the Y chromosome -11 (31.4%). Conclusions. Patients who have genetic abnormalities should receive comprehensive medical and genetic advice. K E Y w o r d s -Male infertility, azoospermia, chromosomal abnormalities, Kleinfelter syndrome, AZF microdeletions

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Diagnosis of geneticforms of azoospermia

Sturov¹,

Myandina²,

Saushev³

et al. 2019

AREM

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“…Every tenth married couple faces the problem of infertility during their reproductive life [1]. Moreover, male infertility accounts for 30-50% [2,3].…”

Section: Introductionmentioning

confidence: 99%

Male Infertility Associated With Obesity

Kozlov¹,

Myandina²,

Faniev³

et al. 2021

ArveMED

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Obesity should be considered as a separate risk factor that contributes to the development of male infertility. Aim. To assess obesity impact level on semen disturbances. Methods. The study included 130 males with fertility disorders, who, depending on the level of body mass index (BMI), were divided into two groups. The first group included 67 men with a BMI of 22,7±2,9 kg/m². The second group included 63 men with 38,6±4,3 kg/m² (p <0.05). Results. The significant tendency to decrease in the levels of LH, FSH, testosterone and an increase in the level of estradiol in men with an increase in BMI compared to men with normal weight was established (p<0.05). In addition, obese men sperm motility was 8.2% worse (p<0.05). Conclusion. In men with obesity and fertility disorders, the concentration and number of motile forms of spermatozoa are significantly lower compared to men with a normal body mass index.

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“…During their development, spermatogenic cells undergo cycles of mitotic and meiotic division, with the subsequent formation of mature spermatozoa with a haploid set [3]. Spermatogenesis occurs under the control of specific genes of the developing gametes and is regulated by a combination of hormones, cytokines, growth factors, synthesized both in the organs of the reproductive system and outside it [4]. Therefore, a violation in any part of the regulation of spermatogenesis leads to the development of male infertility.…”

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confidence: 99%

“…The most severe and critical form of impaired spermatogenesis is nonobstructive azoospermia [2,4]. There are many causes leading to patospermia: both endogenous and exogenous.…”

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confidence: 99%